Choupo-Moting was replaced by Angel Di Maria in the 43rd minute after suffering a knock as the reigning French champions suffered their second defeat in the top-flight this season.
The 30-year-old joins fellow strikers Mauro Icardi, Kylian Mbappe and Edinson Cavani on PSG's treatment table, which leaves 17-year-old Arnaud Kalimuendo as the only centre-forward available for Thomas Tuchel.
Paris Saint-Germain (@PSG_English) September 25, 2019
Gambia's Hassane Kamara led Reims' surprise victory against the hosts at the Parc des Princes with his first-half header before Boulaye Dia's sealed the win with his stoppage-time effort.
The defeat was PSG's first home defeat in a league game since May 2018.
Choupo-Moting has had a good start to the 2019-20 season, matching his tally of three goals in 22 league appearances last term in just five matches this season.