The Hoops hammered Graeme Murty's men when the teams met in the Scottish Cup semi-final earlier this month, claiming an emphatic 4-0 win at Hampden Park.
A similar outcome on this occasion will see Brendan Rodgers' side secure their second piece of silverware of the campaign, as the Hoops target the treble for a second successive season.
The gulf between these teams was great when they met just two weeks ago so it is no surprise that Celtic are chalked up as bet365's 1/2 (1.50) favourites to take all three points.
Rangers have failed to win any of their last 13 matches against the Hoops inside 90 minutes and bet365 go 5/1 (6.0) that Murty's men buck the trend by claiming victory.
The same firm go 100/30 (4.33) that the match ends all square.
Moussa Dembele missed Celtic's defeat against Hibernian last weekend but the French striker is expected to return to the fold for this fixture.
Veteran striker Kenny Miller and captain Lee Wallace have been both suspended by Rangers following a breach of discipline.
Goalkeeper Wes Foderingham and veteran defender Bruno Alves are rated as extremely doubtful for the 'Gers.
Celtic to cruise
Rodgers' side have conceded just three goals in their last six matches against Rangers, keeping a clean sheet in three of the last four meetings between the teams.
Celtic have had a winning margin of more than a single goal in four of their last five victories against Rangers and, so, the 13/10 (2.30) quote for the Hoops (-1) in bet365's handicap market could well offer good value for punters ahead of Sunday's showdown.
Odds correct at time of writing. Please gamble responsibly