Zinedine Zidane's men are 5/4 (2.25) with dabblebet to secure a win in Germany, despite some patchy domestic performances of late. Madrid are already seven points off Barcelona in La Liga but have undoubted European pedigree to call upon.
Meanwhile, Peter Bosz's side are in fine form, topping the Bundesliga with 16 points and a goal difference of +18. The hosts are on offer at 15/8 (2.88) with dabblebet to win this one and the draw trades at 11/4 (3.75).
Dortmund have been ruthless going forward and miserly in defence, conceding their first league goal of the campaign in the 6-1 victory over Borussia Monchengladbach at the weekend. Goals are expected here too with the over 3.5 line available at 19/20 (1.95) while both teams to score is just 1/3 (1.33).
Having been drawn in the same Champions League group last season, both meetings between these sides ended 2-2 and that's at 17/2 (9.50) for bettors who foresee another end-to-end encounter.
With those quotes around the likelihood of a high-scoring game in mind, punters might have to get a little creative with their selections and the goalscorer markets could offer just such an opportunity.
The claims of Pierre-Emerick Aubameyang 8/11 (1.73) and Cristiano Ronaldo 8/15 (1.53) to score are obvious and are unlikely to catch the eye but there's a Dortmund player still offering a potentially juicy pay-out potential after an impressive opening to the campaign.
Maximilian Philipp signed with Dortmund this summer from Freiburg and the Germany Under-21 international has made a brilliant start to his career at Signal Iduna Park, with four goals in his last two starts and his propensity for early strikes in games make him a definite option as far as a wager goes.
Having broken the deadlock against both Koln and Monchengladbach, Philipp is an 8/1 (9.0) shot to be first goalscorer here and 2/1 (3.0) to net anytime with dabblebet. The forward was an unused substitute at Wembley against Tottenham but, if he starts on the left of a front three as he has been of late, then 2/1 (3.0) looks fair about him finding the net.
Not least because Real Madrid's defence has been far from stable this season - the routine 3-0 win over APOEL Nicosia is the only clean sheet Los Blancos have kept in their last seven matches in all competitions - and while the European champions retain favouritism for this game, the value could lie with the home sides' newest star with goals galore expected by the bookmakers.