Having disappointingly lost two of their three matches at the national stadium in last season's Champions League, Spurs have exacerbated talk of a 'Wembley Curse' by taking just one point from their opening two home games this campaign.
Although easily written off as mere superstition, it is undeniable that the players are yet to make themselves at home in Northwest London - leading to a nervousness among the fans that can be felt on the pitch.
Pochettino himself bemoaned a 'lack of focus' after his side conceded a late Chris Wood equaliser in the 1-1 draw with Burnley, which followed Marcos Alonso's 88th minute winner in the previous home defeat against Chelsea.
Whether logical or not, there is sure to be a relatively uneasy atmosphere around the ground should this game remain finely balanced going into the latter stages, particularly given the guests' trend for late goals in this competition.
Having seen 10 goals scored in the last 15 minutes of their 10 Champions League matches last season, Peter Bosz's side are more than capable of adding to the recent spate of late drama at Wembley.
With this in mind, odds of 5/6 (1.83) are well worth backing on a goal being scored from the 76th minute onwards in Tottenham's third consecutive home game, as well as Dortmund's sixth in seven in the Champions League.