Ever since the Maracanazo of 1950, Uruguay have consistently recorded impressive results over La Canarinha, with their most recent meeting seeing them come from 2-0 down to record a 2-2 in Recife last year.
Brazil head to Montevideo in fine form, but know they will have to be at their best to keep their six match winning run going against a Uruguay side who are extremely difficult to beat in the Estadio Centenario.
Both teams will be missing key forward players with Luis Suarez suspended for the hosts, and Gabriel Jesus injured for Brazil. While Suarez has a strong claim to being the best centre-forward in the world, his absence may not be as keenly felt by Uruguay as that of Jesus for Brazil, with La Celeste now accustomed to playing without their talisman.
In his absence, Edinson Cavani can play in a more central role and the forward is the top scorer in CONMEBOL qualifying. Betfair offer him at 23/20 (2.15) to score at anytime and that looks like an attractive option for a player with eight goals in the tournament so far.
Five of those goals have broken the deadlock and the PSG striker is priced at 10/3 (4.33) to score first. Cavani is likely to be supported up front by lively Bordeaux forward Diego Rolan, and the 23-year-old can be backed at 14/5 (3.80) to add to his tally of two qualifying goals so far.
With Gabriel Jesus missing, there will be even more of an onus on Neymar to lead the side and the Barcelona star is priced at 23/20 (2.15) to score anytime. Neymar has scored in four of Brazil's last five qualifiers and remains their most potent goal threat. In Jesus' place is likely to come Roberto Firminho, with the Liverpool player only featuring for 31 minutes of qualifying so far.
He has though managed to score in that half an hour of action, and is priced at 21/10 (3.10) to do so once more. Firminho's club team-mate Philippe Coutinho, meanwhile, is offered at 3/1 (4.00) to find the back of the net although the 24 year old only has one goal in his last 16 matches for club and country.
Elsewhere in the betting, Uruguayan centre-back Diego Godin has scored some big goals for Atletico Madrid this season and is priced at 17/2 (8.50) while Real Madrid midfielder Casemiro can be backed at 9/1 (10.00) to score his first ever full international goal.