Atletico make the short trip to the north of the Spanish capital in excellent form after five consecutive league wins during which time they have conceded just one goal.
Diego Simeone's men are beginning to resemble the well-oiled machine that won the league title three years ago, and they will be confident of getting a result in a stadium where they have won on each of their last three La Liga visits.
Los Blancos meanwhile, have also won five successive league games, and on Wednesday night against Leganes extended their record breaking run of scoring to 51 consecutive games.
That run will surely be put to the test against an Atleti side with the best defence in the division, and a record of two clean sheets in their last three league visits to the Bernabeu.
After 14 months unbeaten at home in La Liga, Real Madrid are understandably favourites, but that run has seen Zinedine Zidane's side produce some impressive comebacks.
This season Real have conceded the first goal at home on six occasions in all competitions, yet only once did they go on to lose the game (against Celta Vigo in the Copa Del Rey).
Atletico for their part have opened the scoring in their last three league games in the Bernabeu and the price of 6/4 (2.50) for them to do so once more should appeal.
However, Real Madrid's capacity for epic finales should not be underestimated and the price of 17/2 (9.50) for Zidane's men to come from behind and win is well worthy of consideration for a value bet.
|Atletico Madrid to score first at 6/4 (2.50) for a 1pt stake with Paddy Power|