They have won their last five matches on their turf and another home win will not be out of place having been tagged as favourites for this tie at odds of (1.083) with Bet365.
A draw at the end of 90 minutes is quoted at an unlikely price of (11.00).
Alaves were knocked out of the Copa del Rey by Valencia in a penalty shoot-out. Though they will be aiming to put the loss behind them, their 14 defeats in the hands of Barca means they will be coming into this tie as massive underdogs with the same betting firm at (26.00).
Barcelona are the highest scoring side in the league this season with 57 goals and the bookmakers are offering (1.25) for over 2.5 goals to surface in the encounter.
Philippe Coutinho - who signed for a club record of £142million, made his much-awaited debut for the Blaugrana on Thursday after coming in for Andres Iniesta.
Prior to his departure from Liverpool, he scored 15 goals and made eight assists in the on-going season. The Brazilian is on offer at (1.72) to score anytime.
Lionel Messi was on target in their last outing and the Argentine is odds on at (1.20) to score anytime.
*Odds correct at the time of writing. Please gamble responsibly.