Mauricio Pochettino's men were held at home by Swansea City last time out, but edged to a narrow EFL Cup win over Barnsley in midweek as a below-par first few weeks for the club continued.
Although Slaven Bilic's side have now collected three clean sheets in a row in all competitions, facing the likes of Dele Alli and Harry Kane is a different story to games against Huddersfield Town, West Brom and Bolton Wanderers.
Shipping 10 goals in their first three league games means the Hammers still have the joint-worst defensive record in the division after five matches, so Kane in particular will be licking his lips.
The England forward has scored five goals in his last five appearances against the Hammers while his record in matches against local rivals is terrific - the double Golden Boot winner has hit 19 goals in 28 Premier League London derbies for Spurs.
After his traditionally barren August, Kane has caught fire in September with six goals scored for club and country already this month, and keeping him quiet looks a challenge beyond the West Ham defence.
With Spurs having already put three goals past Everton in the Premier League and Borussia Dortmund in the Champions League - Kane scored a brace in both victories - it is clear that Mauricio Pochettino's men have plenty of firepower.
And although their record in this fixture is not great, West Ham winning three of their last four home league games against Spurs, including a 1-0 success in May, those poor results should be further fuel for the visitors in Saturday's clash at London Stadium.
Spurs might not have hit top gear yet but they look poised to give someone a real hammering, with Bilic's men looking vulnerable to suffering another heavy defeat this weekend.
With that in mind, Tottenham to beat West Ham with over 4.5 goals scored, enhacned to 6/1 (7.0) by dabblebet, is well worth considering for this game - especially as this bet would have paid out in two of the last four games between the sides.