Unfortunately for Wenger, Jose Mourinho will not make it easy for the Frenchman with the Gunners last win away against United dating back to 2015.
Four spots behind United in the Premier League and clinging to an automatic spot in Europe next season, the Gunners have had a season to forget and are serious underdogs to beat United on their own turf.
But with Wenger officially out, in a few games at least, Arsenal are looking refreshed and determined to send the manager out in the right manner.
Their 4-1 win against West Ham after Wenger's announcement highlighted the extra gear the Gunners should have available to them at the tail end of the season as a result.
With the scores locked at 1-1 after the 80th minute, Arsenal dug that little deeper with Wenger clearly on their mind, and turned on the style to hit three goals in seven minutes.
Style over substance has been a trademark of sorts over the past decade at the Emirates, with flashy skills often failing to compensate for a lack of silverware.
Arsenal's record this season compared to United's suggests that trend has continued because even though the Gunners have scored one more goal than Mourinho's men, they've let in an extra 20 in the process.
That poor defensive record leaves Wenger 17 points behind the Red Devils and ensures the odds are well and truly against him ahead of a final showdown.
Despite sitting second, United have been anything but convincing this season and an Arsenal side with a departing manager spurring them on can't be underestimated.
Though a win away may be beyond them, a draw could well suit both teams and leave Wenger somewhat satisfied considering his patchy record against the Red Devils.
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