Jupp Heynckes' side enjoyed a crushing 5-0 win in last month's first leg tie in Bavaria and the German champions will fancy their chances of another comfortable win here.
Given the gulf in class between the teams at Allianz Arena last month, it is little surprise that the Bayern are as short as 20/33 (1.61) with SportPesa to win this one.
Besiktas are playing for pride at this point and they can be backed at 4/1 (5.0) to win on home soil.
The Turkish team, though, have drawn six of their last seven home matches in this competition and SportPesa go 7/2 (4.50) that this match also ends all square.
Munich boss Heynckes could opt to field some fringe players here, given that the German champions hold such a decisive lead in the tie.
There have been at least three goals scored inside 90 minutes in each of Bayern's last 11 matches in this competition.
There have been goals at both ends in six of Bayern's last seven away matches in the Champions League and SportPesa go 10/19 (1.52) that both teams are on target here.
Preview and predictions
Six of Besiktas' last seven Champions League ties on home turf, however, have produced fewer than three goals.
This match is effectively a dead-rubber following Bayern's 5-0 first leg win and so the Germans may lack their usual intensity on this occasion.
The 7/4 (2.75) quote, therefore, from SportPesa for fewer than three goals to be scored in this game could offer decent value for punters ahead of Wednesday's match.