Barca boast a formidable home record in Europe, where they are unbeaten in five years with 22 wins and two draws from their last 24 games.
Chelsea, though, recorded a famous 2-2 draw in their last visit to Catalonia in 2012 and a repeat scoreline this week would see them qualify for the quarter-finals.
Lionel Messi missed the weekend win over Malaga because of the birth of his son, but will return to the starting eleven here.
Andres Iniesta will miss out for Barca through injury, as will right-back Nelson Semedo.
Chelsea have David Luiz sidelined and Ross Barkley is likely to still be unavailable.
Blues on the attack
Antonio Conte's men know they are out of the competition unless they score on Wednesday, so it will be interesting to see how that conditions their approach to the game.
At Stamford Bridge they looked the better side and twice hit the woodwork before Willian found the back of the net, and the Brazilian caused Barca problems on the counter attack along with Eden Hazard and Pedro.
Barca, for their part, have conceded in six of their last seven matches in the knockout stages of the Champions League and there should certainly be some interest in backing the visitors to score.
Preview and predictions
Both teams to score is priced at 5/6 (1.83) and that should be of interest, with this selection paying out in each of the last three meetings between the sides.