The Basques were the last team to win a league game away to Barcelona back in September 2016, although they will struggle to repeat that triumph on Sunday.
The visitors have improved greatly since the arrival of new manager Abelardo and four wins in their last seven games have lifted them out of the relegation zone.
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Ousmane Dembele remains out for the Blaugrana, but Philippe Coutinho could be in line for his first start after impressing on his debut on Thursday.
However, Barca have a Copa Del Rey semi-final against Valencia in midweek and manager Ernesto Valverde might chose to rest some players on Sunday.
For Alaves, first choice centre-back Rodrigo Ely and defensive midfielder Tomas Pina are both suspended for the trip to Catalonia.
Blaugrana to maintain their strong home record
Even if Valverde chooses to rest some players, Barca should still be far too strong for their visitors.
The Basques may have improved under Abelard,o but their away form remains poor and there is no tougher trip than a visit to the Camp Nou.
Tips and predictions
Barca are priced at 10/11 (1.91) to score over 3.5 goals and this looks a sensible way to back a comfortable home win against an Alaves side missing some key defensive players.