Bafana Bafana head coach Stuart Baxter and his counterpart Kwesi Appiah both named strong teams for the encounter.
Thulani Hlatshwayo started in defence, while Dean Furman was deployed in midfield and Lebogang Mothiba spearheaded the Bafana attack.
On the other hand, the experienced John Boye led the Black Stars defence and new Ghana captain Andre Ayew started in attack alongside his brother, Jordan.
Both teams sized each other up in the opening exchanges as they searched for an early goal in the scorching temperatures in the United Arab Emirates.
Ghana grew into the game and they took control of the encounter with Kwadwo Asamoah and Thomas Partey pulling the strings in midfield.
However, the Black Stars could not seriously test Darren Keet, who is looking to establish himself as South Africa's first-choice goalkeeper in the absence of Itumeleng Khune.
Bafana finished the stronger of the two teams in the first half, with Percy Tau looking lively upfront and he had a chance to open the scoring after South Africa were awarded a free-kick in a promising area.
Thulani Serero was fouled on the edge of the Black Stars box and Tau stepped up and placed his effort wide of the target failing to test Richard Ofori in Ghana goal.
English tactician Baxter unleashed a new team for the second half, which was dominated by Mamelodi Sundowns players, Hlompho Kekana, Tiyani Mabunda, Themba Zwane, Sibusiso Vilakazi and Lebohang Maboe.
While Ghanaian trainer Appiah introduced Samuel Owusu, Mubarak Wakaso and Kwabena Owusu as the Black Stars looked to break the deadlock in the second half.
It was Bafana who threatened first after the restart when Zwane, Vilakazi and Bongani Zungu combined well, but Lars Veldwijk's effort was well-saved by Maritzburg United keeper Richard Ofori.
Keet was then replaced by fellow shot-stopper Ronwen Williams, who was called into action by the Black Stars and he produced a fine save to ensure that the score remained level.
The two teams launched attacks in the closing stages of the game in search of a late winning goal, but it never came and the encounter ended in a 0-0 draw.