The Portugal international failed to find the back of the net away at Old Trafford a fortnight ago, with Paulo Dybala being the hero as the Argentine's goal handed the Italian giants a 1-0 victory to open up a five-point lead at the top of Group H.
Jose Mourinho's side sit second in the group with four points - two ahead of Valencia - though another defeat could put their hopes of progressing to the knockout rounds in danger.
|Game||Juventus vs Manchester United|
|Date||Wednesday, November 7|
|Time||8pm BST / 3pm EST|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial) .
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|TNT USA, Univision Deportes||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on BT Sport 2 and livestreamed on BT Sport Live.
|UK TV channel||Online stream|
|BT Sprot 2||BT Sport Live|
Squads & Team News
|Goalkeepers||Szczesny, Pinsoglio, Perin|
|Defenders||De Sciglio, Chiellini, Benatia, Sandro, Barzagli, Bonucci, Cancelo, Rugani|
|Midfielders||Pjanic, Khedira, Matuidi, Can, Bentancur, Bernardeschi|
|Forwards||Ronaldo, Dybala, Costa, Cuadrado, Kean|
Confirmed Juventus starting XI: Szczesny; De Sciglio, Bonucci, Chiellini, Alex Sandro; Khedira, Pjanic, Bentancur; Cuadrado, Cristiano Ronaldo, Dybala
|Position||Man United players|
|Goalkeepers||De Gea, Romero, Grant|
|Defenders||Lindelof, Bailly, Jones, Smalling, Rojo, Shaw, Darmian|
|Midfielders||Pogba, Mata, Lingard, Pereira, Fred, Young, Herrera, Matic, Garner, McTominay, Hamilton|
|Forwards||Sanchez, Lukaku, Rashford, Martial, Chong|
Confirmed Man Utd starting XI: De Gea; Young, Smalling, Lindelof, Shaw; Herrera, Matic, Pogba; Lingard, Alexis, Martial
Betting & Match Odds
Juventus are priced at odds 8/13 to win according to bet 365 , while a draw is available at 29/10. A win for Man United is priced at 11/2.
A home win over United would send Juventus into the knockout phase as group winners, leaving Mourinho's side to scrap with Valencia for the final qualifying berth.
Lukaku is still recovering from the injury which saw him miss the weekend win at Bournemouth and that leaves him doubtful for Sunday's Manchester derby.
The meeting in Turin will be a reunion for many, with Ronaldo facing his former club and manager once again, and Paul Pogba returning to his old side .
Despite being in fine form in Serie A with seven goals and six assists so far this season, Ronaldo has been unable to continue his prolific Champions League form from last season – and is yet to register in the competition.