Giants Asante Kotoko and Hearts of Oak have been handed second-tier sides Wassaman and Accra Young Wise respectively but while the Porcupines play as hosts, the Phobians will make a short trip within Accra.
Defending champions Bechem United travel to Berekum to lock horns with Chelsea at the Golden City Park in the Brong Ahafo derby while, Liberty Professionals, after coming from behind to defeat Uncle T FC 2-1 at the Carl Reindolf Park, will travel to play Danbort FC.
Nea Salimina cruised past Techiman XI Wonders in a marathon penalty shootouts in the previous round and will welcome yet another second-tier side Steadfast to the Agyeman Badu Park in Dormaa Ahenkro. Ghana Premier League champions Wa All Stars will face Samatex.
All the matches have been scheduled for June 16-18, 2017.
Asante Kotoko vs Wassaman United
Accra Young Wise vs Hearts of Oak
Berekum Chelsea vs Bechem United
Nea Salamina vs Stedfast
FC Samatex 1996 vs Wa All Stars
Medeama vs Elmina Sharks
Amidaus vs Wafa SC
Danbort vs Liberty Professionals