While the title race is still far from over, this encounter could potentially paint a clear picture as to who would be crowned champions come May 2019.
Sundowns have two games in hand and they are only two points behind the Students, who have played 20 league games this season.
This season has been defined by individual brilliance from both sides, with the likes of Gift Motupa, Deon Hotto doing well for the Braamfontein-based side, while Sundowns have had to rely on Themba Zwane and Gaston Sirino among other players.
However, Goal focuses on two of the top players who played for these two teams and checks how they have fared in the last three years at their respective clubs.
Elias Pelembe joined Wits soon after parting ways with Sundowns whom he spent six years with before failing to agree to terms on a new deal.
Highly-rated Sibusiso Vilakazi, who was the Wits captain for many years before moving to Chloorkop, was sold to Sundowns just three seasons ago.
The two players played together at Wits before Vilakazi moved to Tshwane.
Pelembe, originally from Mozambique, spent six years at Sundowns, and he's in his fourth season with the Students. He's closing in on his 100th appearance for the club.
He has won several trophies with Wits, including the MTN8, Telkom Knockout Cup and the PSL titles in the last four seasons.
Domingues is certainly one of the Students' best players, and one who continues to give his all since dumping the Brazilians for the less-fancied but ambitious Wits side.
Under Gavin Hunt, Pelembe has blossomed, and although he enjoys less spotlight compared to when he was at Sundowns, he has done pretty well for the Johannesburg-based outfit.
The fact that he has won silverware with Wits when no one expected his career to stay at the same level, means that Pelembe has allowed his feet to do the talking on the field of play than hogging the limelight for the wrong reasons.
He may have joined Wits on a free transfer, but that hasn't really impacted negatively on his football as he continues to give his all whenever he takes to the field, and perhaps that's why success has followed him even after leaving Sundowns.
Vila, on the other hand, hasn't really been the same player that Sundowns signed in 2016.
He took a bit of time to settle down under Pitso Mosimane, and at times, there were questions raised as to whether or not the move was the right one for him.
However, he improved tremendously in his second season and repaid Mosimane's faith in him, but his third campaign with the Brazilians was marred by a nasty injury which has kept him on the sidelines to this day.
Vilakazi was hot property whilst on the books of Wits, and every big team wanted to sign him until Sundowns won the race for his signature.
He has the Caf Super Cup with Mosimane's men as well as the PSL title which he won last season, but there's still room for improvement, especially looking at the fact that he is only 29 years old.
He has managed 17 goals and seven assists in his 71 appearances for the Tshwane; the record isn't too bad but everyone knows that he can do better, more so because Mosimane hasn't lost faith in him as a footballer.
Pelembe is still far ahead of Vilakazi in terms of his contribution at Wits since joining the club in 2015, and with the Sundowns midfielder still nursing a long-term injury, this could be the Mozambican's chance to further stamp his authority.