They came into this clash hoping to improve their poor away record in the competition having failed to win on the road in the group stage.
Their struggles away from home proved to be a recurring issue as they were sluggish starters and far from their exhilarating best against the Guinean champions.
The Buccaneers were left frustrated in Zimbabwe against group stage debutants FC Platinum on matchday one as the encounter ended in a goalless stalemate.
Milutin Sredojevic's charges then produced another lacklustre performance against the defending champions Esperance de Tunis in Tunisia as they lost 2-0 last month.
Pirates were definitely not able to impose their quick and free-flowing football on their opponents on both occasions and it was the same case in Guinea.
The visitors created few chances which they could not convert, while striker Thamsanqa Gabuza failed to impress after being handed rare start for Bucs.
The decision not to include striker Justin Shonga, who was doubtful ahead of the game due to injury, came back to haunt the Bucs technical team.
Shonga was arguably Pirates' best player during their Champions League campaign - netting four goals prior to the match including a crucial one against African Stars in Namibia in the qualifying rounds.
Sredojevic should have taken a risk by handing Shonga a starting berth in Conakry with Pirates needing a victory to qualify for the quarter-finals.
The Zambian striker had netted twice against the 1978 Caf Winners' Cup champions Horoya at the Orlando Stadium last month.
Shonga was introduced on the hour-mark and he went on to score what proved to be a consolation goal for the 1995 Champions League winners in stoppage time.
Bucs' disappointing Champions League campaign saw them struggle to find their rhythm, especially on the road, while failing to win all of their home matches which also contributed to the team's exit from the competition.
Pirates need to go back to the drawing board and reflect on their poor campaign which saw them finish third in Group B having recorded just one victory from six matches.