Although Akpom was an unused substitute at the Stadio Toumbas, the emphatic win sealed the league title for Rzvan Lucescu's side with a game to spare.
PAOK are currently unbeaten in the Greek top-flight this season with a record of 25 wins and four draws from 29 matches.
They hold an 18-point lead above second-placed Olympiakos with 77 points from 29 minutes.
Akpom who joined the Thessaloniki outfit on a three-year deal from Arsenal last summer, has scored six goals in all competitions this season and he will be hoping to wrap up his impressive debut campaign with a double.
On Thursday, PAOK visit Asteras Tripolis for the return leg of their Greek Cup semi-final clash with a 2-0 advantage.