Brazil beat Mexico 2-0 to knock them out in the round of 16, prompting Neymar to hit out at Guardado's side in his post-match comments, saying: "They talked too much, and now they are going home."
Tensions between the two sides did not end there, as Mexico star Layun criticised Neymar back over his theatrics on the field, telling reporters: "This is football. If he does not want to be touched he should try doing something else. He is more concerned about being on the floor. If he wants to lie down, he should go home and sleep."
But the Selecao were undone by Belgium in the quarter-finals as an own-goal from Fernandinho and a Kevin De Bruyne strike rendered Renato Augusto's second-half strike no more than a consolation.
"And now who is going home?" he wrote in an Instagram story.
Neymar was responsible for just one of Brazil's nine shots on target as they crashed out against Belgium, leaving him with just two goals to show for his efforts in Russia.