Following a surprise 1-0 loss to Brighton, Jose Mourinho will no doubt be aiming to finish their league campaign on a high with a victory over David Moyes' side. Forward Alexis Sanchez returns to the fold while Romelu Lukaku and Marouane Fellaini miss out due to injury.
Wednesday's trip gives Patrice Evra a chance to face his former club – the Frenchman spent eight years at Old Trafford. Fellow ex-Red Javier Hernandez, however, will miss the fixture due to an ongoing recovery from a knee injury.
West Ham sit comfortably 15th place and five points off the relegation zone, having won 29 points from 25 games since the Scot took over from Slaven Bilic last November.
Mourinho has confirmed that veteran and club captain Michael Carrick will start the last game of the season – which will be his last appearance for the club – following the announcement of his retirement as a player . He will take up a coaching role with the club come the end of the campaign.
|Game||West Ham vs Manchester United|
|Date||Thursday, May 10|
|Time||7:45pm BST / 2:45pm ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBCSN||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Premier League and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Premier League||Sky Go|
Squads & Team News
|Position||West Ham players|
|Defenders||Reid, Cresswell, Zabaleta, Collins, Ogbonna, Byram, Masuaku, Evra, Rice|
|Midfielders||Kouyate, Lanzini, Obiang, Noble, Mario, Haksabanovic, Antonio, Fernandes, Quina, Holland, Cullen|
|Forwards||Caroll, Hugill, Hernandez, Arnautovic, Lopez|
Both Marko Arnautovic and James Collins both returned to training and are potentially available for selection. Michael Antonio, Winston Reid and Sam Byram have been excluded due to injury and Hernandez is still ruled out.
Potential West Ham starting XI: Adrian; Cresswell, Ogbonna, Rice; Masuaku, Zabalata, Kouyate, Noble; Lanzini, Joao Mario; Arnautobic.
|Position||Manchester United players|
|Goalkeepers||De Gea, Romero, Pereira|
|Defenders||Lindelof, Bailly, Jones, Rojo, Smalling, Blind, Young, Shaw, Valencia, Darmian|
|Midfielders||Pogba, Lingard, Carrick, Herrera, Fellaini, Matic, Mata|
|Forwards||Sanchez, Martial, Rashford|
Lukaku is unavailable and in a race to recover from his ankle injury in time for the FA Cup final, while Fellaini suffered a muscle problem against Watford on Sunday. Alexis Sanchez and Phil Jones are available after missing the loss to Brighton.
Potential Manchester United starting XI: De Gea; Valencia, Jones, Bailly, Young; Matic, Herrera, Pogba; Lingard, Sanchez, Rashford.
Betting & Match Odds
West Ham are priced at 7/2 to win, while a draw is available at 13/5 and Man United are 4/5 to claim the victory.
Mourinho's side have just two Premier League games left to secure a second-placed finish, and a win against West Ham would be enough to seal the deal ahead of Tottenham close on their heels.
Just a draw against the Londoners would be enough to see Mourinho achieve United's highest points tally following Sir Alex Ferguson's departure, as well as giving some young fringe players the opportunity to get a chance to feature in the first-team.
The Portuguese boss, however, will have one eye on the FA Cup final against Chelsea on May 19 and will be saving the fitness of his key players. Apart from the injuries sustained by Lukaku and Fellaini, Mourinho has a fully-fit squad and will likely shuffle his side following the disappointment of the loss to Brighton.
Despite saving West Ham from relegation danger since assuming the post in November, the club have yet to offer the Scotsman a permanent contract. West Ham were in 18th place before Moyes guided them to safety, but he has revealed that he decided to remain at the London Stadium despite getting other offers from other clubs.
“I could have joined a Premier League club during the season here, when I was West Ham manager,” he told reporters.
"I chose not to. But I've got other things if it's not renewed. It's not a problem.”
“There is nothing scheduled [about talks]. We always said, even in November, don't even ask me because we won't have an idea before the end of the season."