The 26-year-old has been out of the Black Stars since the disastrous 2014 Fifa World Cup campaign in Brazil.
"Of course I am interested in returning to the team," Opare told Bundesliga Vibes.
"Ghana is my country and if they invite me I will still represent my country.
"For the moment, we are not in a good position [in 2018 World Cup qualifying]; we have two qualification matches to play."
Opare's absence from the national set-up has been due to a combination of injury and unstable club career.
With Ghana currently short on right-back options, Opare could earn a recall for the Black Stars' clash with Uganda in the global showpiece qualifiers next month.
In September's double-header against Congo, Columbus Crew fullback Harrison Afful was forced to play in both games despite being declared unfit due to a lack of quality alternatives.
Ghana currently sit third in Group E, four and two points behind Egypt and Uganda respectively.