If Pep Guardiola’s men are to replicate the class of 2016 and keep their hopes for a historic quadruple alive, they must overcome a 1-0 deficit .
Spurs have the advantage thanks to a strike from Son Heung-min as they chase a first European Cup semi-final since 1962, when they were defeated 4-3 on aggregate by Benfica.
Ahead of another meeting between the pair in the Premier League on Saturday, who will prevail?
|Game||Manchester City vs Tottenham|
|Date||Wednesday, April 17|
|Time||8pm BST / 3pm EST|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial) .
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|TNT USA / Univision Deportes / UniMas||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on BT Sports 2 and BT Sports 4K UHD. It can be streamed on BT Sport Live.
|UK TV channel||Online stream|
|BT Sport 2 / BT Sport 4K UHD||BT Sport Live|
Squads & Team News
|Position||Manchester City players|
|Goalkeepers||Ederson, Grimshaw, Muric|
|Defenders||Walker, Danilo, Laporte, Sandler, Garcia, Stones, Delph, Otamendi, Kompany|
|Midfielders||Sterling, Gundogan, Sane, B. Silva, D. Silva, Mahrez, Foden, Fernandinho, De Bruyne|
Manchester City have seen Fernandinho train after missing Sunday’s victory against Crystal Palace, but the Brazilian is only fit enough for the bench. Sergio Aguero will start after overcoming a late injury concern.
Oleksandr Zinchenko, however, continues to struggle with a hamstring problem and is out along with Claudio Bravo.
Bernardo Silva returns to the XI after missing the first leg last week with injury, as does Benjamin Mendy.
Manchester City starting XI: Ederson, Walker, Kompany, Laporte, Mendy, Gundogan, D. Silva, De Bruyne, B. Silva, Sterling, Aguero
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Trippier, Rose, Alderweireld, Vertonghen, Sanchez, Walker-Peters, Foyth, Davies|
|Midfielders||Son, Wanyama, Sissoko, Eriksen, Lucas, Marsh, Skipp, Lamela, Alli|
Tottenham boss Mauricio Pochettino does have his problems ahead of this clash, with Harry Kane sidelined due to a significant ankle injury.
After breaking his hand in the first leg, Dele Alli is fit enough to start, while Serge Aurier, Eric Dier and Harry Winks are all sidelined.
Erik Lamela, who has not played for six weeks, is fit enough for the bench.
Tottenham starting XI: Lloris; Trippier, Alderweireld, Vertonghen, Rose; Sissoko, Wanyama; Eriksen, Alli, Son; Lucas
Betting & Match Odds
Man City are red-hot favourites to win the game according to bet365, who price Guardiola's side at 2/7. Spurs are 10/1 to spring an upset and win again. A draw is available at 5/1.
Manchester City manager Pep Guardiola believes his side are entering the most important week of the season , with Champions League and Premier League clashes with Tottenham as the Citizens chase all four major titles.
Although they lie second in the Premier League two points behind Liverpool , they hold a one-game advantage. The situation is equally delicate in the Champions League, in which they trail Spurs 1-0 after the first leg at the Tottenham Hotspur Stadium.
That adds up to make the few days decisive in the Spaniard’s eyes.
“If we don't win these games, we will be out in two competitions. They are finals for us,” he said.
“All the games are tough. We don't have rest. We play nine, 10 or 11 games more than Liverpool and I love this challenge.”
He might have played down his side’s chances of completing a clean sweep of titles this season, but he has been bullish about their prospects of progression in Europe to reach the final four.
City have reached such heights only once previously in their history, but their lack of away goal complicates their task ahead of this return match.
“If you ask me what is going to happen, we'll be in the semi-finals; that is what I feel right now,” Guardiola told Sky Sports.
“It's what I felt right after the game and when I reviewed the game. Maybe I'm wrong but what I feel now, we'll be in the semi-finals.
“The result is not ideal but it's not a disaster. We are able to score goals and we are going to do it.”
Sergio Aguero saw his penalty saved early in the first leg by Hugo Lloris, and the World Cup winner has urged his Tottenham team-mates to take an aggressive approach into this game .
“Wednesday is going to be a different game. We have a small advantage but everything can turn very quickly,” he warned.
“It is important to come here with ambition, stick with our basics. If we come here with the mentality to score goals it is going to make things tough for Man City.
“We know we will suffer but it is important we are ambitious.”
Having described his penalty stop as a “key” moment in the first leg, he went on to discuss the wider-reaching consequences of the save.
“We know in the Champions League it is important not to concede a goal at home. It can help you for the return game away,” he said. “But we know we are facing one of the best teams in Europe, they have a lot of quality in the squad and can score a lot of goals if the opponent shows weaknesses.”
Spurs’ challenge is made all the more complicated by the absence of Harry Kane due to an ankle injury, while Dele Alli will face a fitness test before the clash.
Any edge City can get as they chase a first European title, they will seek to profit from, particularly as this is the greatest threat to their quadruple challenge to date this season.