Spurs kick off the first leg of their last-16 tie against the Bundesliga giants on Tuesday, as they bid to continue their impressive recent form.
Mauricio Pochettino's side have won their last three Premier League games to reignite their title hopes, with just five points separating them and leaders Manchester City.
The World Cup winner produced a string of sensational saves to deny the Foxes and feels that the club's supporters could make a huge difference in their latest European outing.
"We need the stadium to push, to help us - in some days it's difficult to deal with Wembley but hopefully, in this big game we'll receive this help from the crowd.” Lloris told the Telegraph.
Tottenham have had to cope without key squad members Harry Kane, Dele Alli and Moussa Sissoko in recent weeks, grinding out wins despite being short on quality in the final third.
Dortmund represent a step up in class opposition wise for the North Londoners and Lloris is wary of the threat they pose.
"They [Dortmund] play fantastic football,” he added. “They have so many fantastic players and I'm not surprised they're top of the league in Germany. The manager is very good with a great idea of football. It's going to be very, very difficult. We need to obviously improve team performance.
"In terms of performance, we have to do better if we want to dream of big achievements. But in terms of mentality, spirit you cannot ask more.
"We won [against Leicester] but against a bigger side we couldn't have won that type of game. We won the game thanks to our spirit and character. For sure we'll improve. We need to deal with a few more games and then hopefully the squad will be full again until the end.”
Lloris is widely revered as one of the best goalkeepers in English football and he had to be at his best to deny Jamie Vardy from the penalty spot at the weekend.
After James Madison was fouled the Leicester front-man took the kick, despite having only just been introduced from the bench, which raised more than a few eyebrows among the visiting fanbase.
The Spurs shot-stopper revealed how relieved he was after saving Vardy's strike, insisting that moment was a turning point in the contest.
“Yes [I was surprised], because his first touch is a penalty,” Lloris added. “At the same time, he's a great player so it's not a problem for him. It was a good moment for me and the team because at that moment if we conceded a goal the game would have changed completely.
“I know him [Vardy] a little more than other players. He usually shoots strong and he can go everywhere. You need intuition and a bit of luck.”