The manner of that triumph, in tandem with the sensational form of Mohamed Salah, sees the Reds installed as favourites to reach the final, but they cannot rest on their laurels.
Indeed, Roma's route to the semi-final was similarly spectacular as they stunned Barcelona and they will be ready to punish any complacency on the Premier League side's part.
|Game||Liverpool vs Roma|
|Date||Tuesday, April 24|
|Time||19:45 BST / 14:45 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|Fox Sports 1 / Fox Deportes||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on BT Sport 2 and it can be streamed live online using the BT Sport app.
You can also follow updates from the game live on Goal.
|UK TV channel||Online stream|
|BT Sport 2||BT Sport app|
Squads & Team News
|Goalkeepers||Karius, Mignolet, Ward|
|Defenders||Clyne, Van Dijk, Lovren, Klavan, Moreno, Robertson, Alexander-Arnold|
|Midfielders||Wijnaldum, Milner, Henderson, Mane, Oxlade-Chamberlain, Can|
|Forwards||Firmino, Salah, Ings, Woodburn|
Defender Joel Matip has been ruled out for the rest of the season, while Nathaniel Clyne is also unlikely to feature. Emre Can is a concern and Adam Lallana is also on the sidelines.
Potential Liverpool starting XI: Karius; Alexander-Arnold, Lovren, Van Dijk, Robertson; Henderson, Milner, Oxlade-Chamberlain; Mane, Salah, Firmino.
|Goalkeepers||Alisson, Romagnoli, Skorupski|
|Defenders||Luca Pellegrini, Juan, Capradossi, Fazio, Pere, Karsdorp, Manolas, Kolarov|
|Midfielders||Nainggolan, Strootman, Lorenzo Pellegrini, De Rossi, Under, Gonalons, Florenzi, Gerson|
|Forwards||Perotti, Dzeko, Schick, Defrel, El-Shaarawy|
Roma will certainly be without defender Rick Karsdorp, who is continuing his recovery from a cruciate ligament injury, while forward Gregoire Defrel is nursing an ankle issue.
The Serie A side went with a 3-5-2 formation in their historic comeback against Barca, but may opt for a more conservative 5-4-1 approach away from home.
Potential Roma starting XI: Alisson; Kolarov, Manolas, Juan, Fazio, Florenzi; De Rossi, Nainggolan, Strootman, Under; Dzeko.
Betting & Match Odds
Liverpool are favourites to win the first leg at 1/2, with Roma's chances rated at 5/1. A draw at Anfield is a 16/5 bet.
Ahead of the first encounter the Reds are 2/5 to qualify for the final, while the Giallorossi are 7/4.
The Champions League semi-final clash between Liverpool and Roma this season evokes plenty of of intrigue, not least because the two teams were not expected to make it this far into the tournament.
It is, of course, a repeat of the 1984 European Cup final, which the Reds won on penalties in Rome, something that Carlo Ancelotti - who was a member of the Giallorossi squad at the time - believes will act as a further incentive for Italians.
As well as that, it is a game that sees the return of Salah to his former club, having joined Klopp's men from the Giallorossi ahead of the 2017-18 season last summer, and he will no doubt be key to any success the hosts will have on Tuesday, even if his former team-mate Kevin Strootman says they have a 'special plan' for him.
Both sides come into the game in good form, with Liverpool on a seven-match unbeaten run, while Roma have been buoyant following their incredible victory over Barca, picking up two wins and a draw in the fixtures since.
With the Anfield crowd behind them on Tuesday, Liverpool will hope to put the tie out of sight at home, but Roma have shown that they are not the kind of team to simply roll over.