The Italian, who struggled for regular game time under Jose Mourinho, was brought back into the Red Devils fold for an FA Cup third round win over Reading.
That was his first outing since figuring in the 3-1 defeat to Liverpool which brought about a change in the dugout at Old Trafford.
The 29-year-old has seen his future called into question on a regular basis of late, but he is looking for more minutes amid fierce competition for places at an ambitious club.
Darmian told United’s official website of his outing in the centre of defence: “I can play there.
“Of course I play at right-back and left-back, for me it doesn’t matter. I try to do my best every time and I try to help the team to reach the victory.
“Sometimes I’ve played in a back three so it’s not a problem for me. Of course I’m more of a defender than an attacking player, but I have to help the team.”
He added: “We have 25 or 26 very good players.
“It doesn’t matter who plays from the beginning but everyone has to be ready, especially in the Premier League and in England because we have a lot of games so everyone has to be ready.”
United’s win over Reading stretched their faultless start under interim boss Solskjaer to five games – seeing the club hit a 73-year high in the process.
Three more points in that contest would help to drag the Red Devils back into the battle for a top-four finish, with the importance of the fixture not lost on any of those in Manchester.
Darmian added: “I think it’s a very good game and an important game for us against a rival.
“It would be three massive points [if we win] and we have to prepare ourselves in a good way. We have to be focused and, of course, we will be going there for the victory.”
United are currently six points adrift of the Champions League spots, but still have 17 games in which to try and bridge that gap and force their way back to European football’s top table.