Arsene Wenger's side saw off West Ham with ease in midweek but their tumultuous situation in 2017 has left them with a mountain to climb to qualify for next season's Champions League.
They will be in for a tougher night against Palace, who had won four in a row to leave the relegation zone before defeat to Southampton on Wednesday.
|Game||Crystal Palace vs Arsenal|
|Date||Monday, April 10, 2017|
|Time||20:00 GMT, 15:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on Sky Sports 1 and by stream via the Sky Go app.
|UK TV channel||Online stream|
|Sky Sports 1||Sky Go|
In the US, the match will be available to watch live on television on NBCSN and by stream via NBC Sports Live.
|US TV channel||Online stream|
|NBCSN||NBC Sports Live|
SQUADS & TEAM NEWS
|Position||Crystal Palace players|
|Defenders||Ward, Delaney, Kelly, Fryers, Sakho|
|Midfielders||Zaha, Lee, McArthur, Sako, Ledley, Puncheon, Townsend, Flamini, Schlupp, Milivojevic|
Crystal Palace have a long injury list to contend with, with Yohan Cabaye and Loic Remy the latest to be added to it after picking up calf strains.
Scott Dann, Patrick van Aanholt and James Tomkins are all unavailable at the back and Fraizer Campbell's absence leaves Christian Benteke as Palace's only fit centre forward. Steve Mandanda, Pape Souare and Connor Wickham are long-term absentees.
James McArthur could return after missing two games with back spasms.
Potential starting XI: Hennessey; Ward, Kelly, Sakho, Schlupp; Milivojevic, Ledley; Townsend, Puncheon, Zaha; Benteke.
|Defenders||Gibbs, Mertesacker, Gabriel, Monreal, Bellerin, Mustafi|
|Midfielders||Ozil, Oxlade-Chamberlain, Ramsey, Coquelin, Elneny, Xhaka|
|Forwards||Giroud, Walcott, Alexis, Welbeck|
Emiliano Martinez will start in goal again for Arsenal as Petr Cech (calf) and David Ospina (back) are not fit to return. Matt Macey, who has been recalled from a loan at Luton Town, will serve as his backup.
A number of younger players featured for Arsenal's Under-23 side earlier on Monday and are therefore out of contention for the first-team game. They are Alex Iwobi, Yaya Sanogo, Carl Jenkinson, Rob Holding, Jeff Reine-Adelaide and Ainsley Maitland-Niles, as well as the out-of-favour veteran Mathieu Debuchy.
Santi Cazorla is a long-term absentee and no indication has been given that Lucas Perez is ready to return after a thigh strain, but Francis Coquelin is back after missing the West Ham match due to a family issue.
Potential starting XI: Martinez; Bellerin, Mustafi, Gabriel, Monreal; Elneny, Xhaka; Walcott, Ozil, Alexis; Welbeck.
BETTING & GAME ODDS
Arsenal are 8/11 favourites to record an away victory, according to Oddschecker, with Palace priced at 4/1 and the draw available at 16/5.
At 15/4, Alexis Sanchez is the frontrunner to be the first goalscorer, with Olivier Giroud available at 9/2 and Christian Benteke rated the most likely to strike for the hosts at 7/1.
With all their top-four rivals winning, there is not much upside for Arsenal in this Monday night clash; win and they are simply keeping pace with the teams above them, while a loss would deal a potentially terminal blow to their long streak of qualifying for the Champions League.
The Gunners trail Manchester City by seven points with two games in hand and Liverpool by nine with three games spare. The presence of Manchester United also complicates matters, though a win against Crystal Palace will boost the Gunners back above the Red Devils.
A comfortable victory over West Ham will have boosted confidence but, given the state the Hammers are in, that was really non-negotiable. Palace, who are not quite clear of the relegation battle, are a different proposition having won four of their past five games, including one at Chelsea.
Sam Allardyce's men are injury-hit but cannot afford to take their foot off the gas yet, and in Wilfried Zaha and Christian Benteke they have attacking threats capable of asking more questions of an Arsenal side without Laurent Koscielny and Petr Cech than West Ham did.
Mamadou Sakho has also bolstered their defence since joining on loan from Liverpool, and it will be interesting to see if Arsene Wenger rotates his attack after a midweek game or sticks with the Walcott-Ozil-Alexis-Welbeck front four that seems to currently be his best bet.
With a series of difficult fixtures waiting at the end of April and into May, nothing less than six points from six will do for Arsenal against Palace and Middlesbrough in their next two.