Both teams square off in the first semi-final game at the National Stadium, Dar es Salaam on Wednesday afternoon.
The Golden Eaglets qualified for the last four as Group A winners, having yet to lose a game in the competition so far.
Their Guinean counterparts - whose only loss came against Cameroon - are wary of the threat Manu Garba's boys pose. According to their coach, they are not short on confidence to upstage the Nigerians.
“We will face Nigeria with confidence as our target is to play in the final and we are fully prepared for a tough semi-final duel with Nigeria,” Camara told the Caf website.
“We are gunning for success and the appetite to push harder, as well as the confidence among my players, is growing each day.
“We are prepared to win this game, and we will do it in appreciation of the support that we are getting back home and other parts of the world.”
The winner of this semi-final tie will face either Cameroon or Angola in the final of the competition.