United kicked their campaign off with a hard-fought 2-1 victory at home to Leicester on Friday night with Paul Pogba and Luke Shaw opening their goalscoring accounts for the 2018-19 campaign.
Brighton, however, started proceedings with a disappointing 2-0 loss at Watford and face a difficult run of fixtures in which to find their feet, starting with United's visit this weekend.
Here is everything you need to know ahead of Sunday's fixture.
|Game||Brighton vs Man Utd|
|Date||Sunday, August 19|
|Time||4pm BST / 11am ET|
TV Channel, Live Stream & How To Watch
In the United States (US), the game will be shown on NBC Sports and livestreamed on the NBC Sports app.
|US TV channel||Online stream|
|NBC Sports||NBC Sports app|
In the United Kingdom (UK), the game can be watched live on Sky Sports on streamed live online on the Sky Go app.
|UK TV channel||Online stream|
|Sky Sports||SkyGo app|
Squads & Team News
|Goalkeepers||Ryan, Button, Steele|
|Defenders||Bruno, Montoya, Bong, Suttner, Bernardo, Duffy, Dunk, Balogun, Schelotto|
|Midfielders||Knockaert, March, Jahanbakhsh, Izquierdo, Stephens, Propper, Bissouma, Gross, Kayal, Towell|
|Forwards||Murray, Andone, Locadia, Hemed|
Bruno was forced off with an injury against Watford, replaced by Gaetan Bong before new-signing Bernardo was switched to the right of defence.
Summer signing Martin Montoya may come in to make his debut, while Yves Bissouma is pushing for a place in midfield.
Solly March may drop out of the team following a quiet display against Watford, with record-signing Alireza Jahanbakhsh an option to replace him.
Possible Brighton XI: Ryan; Montoya, Duffy, Dunk, Bong; Knockaert, Jahanbakhsh, Stephens, Propper, Gross; Murray
|Position||Man Utd squad|
|Goalkeepers||De Gea, Grant, Romero, O'Hara|
|Defenders||Lindelof, Bailly, Jones, Smalling, Rojo, Young, Dalot, Shaw, Valencia, Darmian|
|Midfielders||Pogba, Mata, Lingard, A. Pereira, Fred, Fellaini, Matic, Herrera, McTominay|
|Forwards||Sanchez, Lukaku, Martial, Rashford|
Jesse Lingard, Nemanja Matic and Antonio Valencia have all returned to first-team training ahead of the trip, having missed out against Leicester.
The United trio are unlikely to play a part, however, with Mourinho saying: "They are fully fit but not yet ready to play or even to be selected, I think, and that’s it."
Possible Man Utd XI: De Gea; Young, Bailly, Lindelof, Shaw; Fred, Pereira, Pogba; Mata, Lukaku, Alexis
Betting & Match Odds
United are heavy favourites to collect the points on Sunday, with an away win priced at 5/6 with Bet365. Brighton are placed at 17/4, while a draw is 5/2.
United's 2-1 victory over Leicester on the opening day was overshadowed by stand-in captain Pogba's post-match comments.
The Frenchman intensified speculation of disharmony at Old Trafford when questioned on his relationship with his manager, saying: "There are things I can say and there are things I cannot say... otherwise I will get fined."
On Friday, however, Mourinho moved to reject reports that the two were involved in a behind-the-scenes feud and confirmed him as captain for Sunday's game at Brighton.
"The truth is we are together for two years and a couple of weeks and I've never been so happy with him as I am now. That's the truth," Mourinho told reporters.
"I cannot demand more from him, I cannot ask more from him. He comes here on Monday [before the Leicester game], he trains for three days, I asked for his support, for his contribution in an important match for us when the team had difficulties, and he did it did better and for more time than we could expect."
On his opposite number Chris Hughton, Mourinho said: "Chris is a great coach. They have good players, a good team, a beautiful stadium, but they're difficult to play against.
"They know how to play and they’ve kept the same team, they bought a few new players."
He will continue in Mourinho's midfield on Sunday and Albion boss Hughton is fully aware of the threat the 25-year-old poses.
"He's a very, very good player, there's no doubt so we have to be guarded against that tactically," Hughton said. "But no special measures.
"He's capable of having a very good season. I think he showed that in the summer, I think he's showed that in good periods at United.
"I think he's a wonderful athlete, can certainly break very, very well from midfield and I think what he has shown is a passing ability that he's got.
"He's a wonderful all-round footballer."