There’s a rare sense of optimism around Old Trafford this week.
The loss to Spurs meant his side had lost two of their last five Premier League home games, as many as they had in their previous 43 at Old Trafford combined.
The Portuguese manager, so used to finding himself leading league tables, instead found himself as one of the frontrunners in the Premier League sack race.
Third-season syndrome, it appeared, was kicking in again.
The much-criticised Paul Pogba was superb. And Man Utd fans were buoyed by the rare sight of seeing him joined in a starting line-up by both Anthony Martial and Marcus Rashford.
Joined by two natural full-backs in Luke Shaw and new-boy Diogo Dalot, United cruised to victory in Switzerland in what could yet prove a turning point in their season.
But only if Mourinho can get one over on an old friend.
If Mourinho can mastermind a win over his old pupil, then Man Utd may well re-join the title race. Defeat at the hands of young, modern manager, however, would pose more questions over whether his time has passed.
The formbook is on his side: Man Utd have won their last six league games against Wolves at Old Trafford.
And Wolves have scored just two goals on their previous seven visits to Old Trafford in the top-flight.
Mourinho has never suffered back-to-back home league defeats in his managerial career and Man Utd have lost just one of their last 49 Premier League home games against promoted sides.
Wolves, however, have won their last two Premier League games and are out to make it three in a row in the top-flight for the first time since March 1980.
The stakes are high. The pressure is on.