United States men's national team star Gio Reyna has limped off the field in a club match for Borussia Dortmund after just six minutes of action.
Reyna, who has dealth with injuries all season, was consoled by team-mate's as he exited Friday's game against Stuttgart.
He had only just returned from a long-term hamstring injury.
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Watch: Reyna's tearful exit
Reyna has missed more than 100 days to injury this season alone, as muscles in his legs have repeatedly let him down.
He's trying to be at full fitness and form for the 2022 World Cup in Qatar, and so the latest setback had a harsh emotional effect.
What has been said?
Dortmund coach Marco Rose was asked about Reyna's injury after the game.
He told DAZN: "Gio is once again exhausted. That's very bitter."
Rose continued to Sky: "It's a drama, you really have to say that.
"A really, really great footballer, fine person. If he stays healthy he will be world class. I'm not leaning too far out of the window. We will support him in everything."
Reyna was not the only Dortmund man to sustain an injury in the game, as Mahmoud Dahoud had to be taken off in the first half because of a shoulder problem, while Mats Hummels did not emerge for the second half because of a suspected hamstring issue.
The latest fitness issues come in the wake of reports in Germany claiming the club are set to part ways with long-term physiotherapist Thomas Zetsmann as he has been blamed for the recurring problems.
But Rose has hit back at such claims, saying: "It annoys me for the boys. We are extremely professional.
"The discussion about our physiotherapist that week was a farce. Zetze has been with the club for 16 years. An excellent physiotherapist, a really great person, very popular with the boys. And then he's linked to the injuries.
"It's important to me that we can get that straight. It annoys me."