Jurgen Klopp's side currently lead the way in Group E and they are one point ahead of Tuesday's opponents coming into the game.
The teams shared the spoils when they met at Anfield in September, but Reds fans will be hopeful that they can snatch maxmum points in Spain.
|Game||Sevilla vs Liverpool|
|Date||Tuesday, November 21|
|Time||19:45 GMT / 14:45 ET|
TV CHANNEL & LIVE STREAM
In the United Kingdom (UK), the match will be available to watch live on television on BT Sport 2 and by live stream using the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 2||BT Sport app|
In the United States (US), the match will be available to watch live on television on Fox Soccer Plus and by live stream using the Fox Soccer Match Pass, as well as WatchESPN.
|US TV channel||Online stream|
|Fox Soccer Plus||Fox Soccer Match Pass / WatchESPN|
SQUADS & TEAM NEWS
|Goalkeepers||Rico, Soria, Perez, Soriano|
|Defenders||Corchia, Kjaer, Lenglet, Carrico, Escudero, Pareja, Mercada, Carmona, Amo|
|Midfielders||Krohn-Dehli, Montoya, Banega, Correa, Geis, Pizarro, N'Zonzi, Navas, Sarabia, Ganso, Vasquez, Lasso, Curro, Pozo, Brice|
|Forwards||Ben-Yedder, Muriel, Nolito, Fernandez|
Sevilla will have to make do without a number of defenders for the visit of Liverpool, with Daniel Carrico and Nicolas Pareja injured, while Sebastien Corchia remains a doubt after being taken off in Saturday's win over Celta Vigo.
The likes of Wissam Ben-Yedder and Jesus Navas sat out that game, but should come back into contention for Tuesday.
Potential Sevilla starting XI: Rico; Escudero, Kjaer, Lenglet, Geis; N'Zonzi, Pizarro, Banega, Navas; Ben-Yedder, Correa.
|Goalkeepers||Karius, Mignolet, Ward|
|Defenders||Lovren, Gomez, Klavan, Moreno, Robertson, Matip, Flanagan, Masterson, Alexander-Arnold|
|Midfielders||Wijnaldum, Milner, Coutinho, Henderson, Grujic, Lallana, Oxlade-Chamberlain, Can, Ejaria|
|Forwards||Firmino, Salah, Sturridge, Mane, Solanke|
Liverpool are still without Adam Lallana and Nathaniel Clyne, but they should be boosted by the return of Joel Matip, who was carrying a slight injury.
Joe Gomez could come into the team having sat out Saturday's win over Southampton, while Lorius Karius is expected to replace Simon Mignolet in goal.
Potential Liverpool starting XI: Karius; Moreno, Matip, Lovren, Gomez; Wijnaldum, Henderson, Coutinho; Salah, Mane, Firmino.
BETTING & MATCH ODDS
Despite being away from home, Liverpool are slight favourites at 8/5 according to dabblebet. Home side Sevilla are priced at 17/10 and a draw is considered a 5/2 bet.
Liverpool endured a difficut period following their 2-2 draw against Sevilla back in September, winning just two of their subseqeunt eight fixtures, but they have rediscovered some good form this month.
The Reds have tallied four successive victories since their embarrassing 4-1 loss to Tottenham in October and they have scored at least three goals in each of those wins, meaning they arrive in Andalusia full of confidence.
While they struggled to overcome Eduardo Berizzo's side on home turf a number of months go, Klopp's men are getting into a rhythm this time round and they will be aiming to pick up three points to ensure their place among the last 16.
Indeed, the fact that Sevilla utterly capitulated against Spartak Moscow - losing 5-1 - in October demonstrates that they can be unravelled and Klopp can certainly use that in his pre-match preparations.