The Belgian midfielder spent six seasons at Goodison Park before following David Moyes to Old Trafford in 2013, having made 133 appearances for the Merseyside club.
Fellaini played a number of different midfield roles at Everton and in his final season at the club he was his side's top goal-scorer with 12 goals.
While his United career was somewhat underwhelming, appearing just 77 times for the club, Howard became a hero a Everton during a decade at Goodison Park.
The United States international returned to his homeland last summer, joining the Colorado Rapids, after almost 400 games for the Toffees.
While not the most talented of the prestigious 'Class of 92', Neville was afforded 386 United appearances before being shipped to Everton in 2005.
Neville enjoyed a playing career spanning over 500 Premier League games, with almost another 200 in cup competitions, and lifted the title six times at Old Trafford.
The Frenchman never quite reached the level of performances he displayed in a Southampton shirt, though did enough at Old Trafford to convince Everton to spend around £24 million on him once it became clear that his days in Manchester were numbered.
Schneiderlin is now a key part of Ronald Koeman's Toffees side and will make life difficult for United when he returns to the club on Sunday.
The £75 million man. Romelu Lukaku's record-breaking transfer from Everton to United is already proving a success, with the Belgian striking six goals in as many games across all competitions.
His move from Everton will be fresh in the minds of Sunday's away support and there is an inevitability about him playing a leading role in the proceedings this weekend.
Having progressed through the United academy, Cleverley went onto make 89 appearances for the Red Devils but the England international never won over the Old Trafford faithful.
Cleverley spent just one full season at Goodison before leaving on loan for Watford, where he has now signed a permanent deal.
Saha spent five seasons under Sir Alex Ferguson at Old Trafford, picking up two top-flight trophies and the 2007-08 Champions League.
The Frenchman struck 43 goals in 12 Red Devils appearances before his four seasons at Goodison, where he scored 35 goals in 115 appearances.
One to forget for both sets of fans. Blomqvist made 25 appearances for United during a three-year, injury-laden spell at Old Trafford before joining Everton on a free transfer.
The Sweden international mustered just 15 Premier League appearances for the Toffees before leaving for Charlton Athletic in 2002.
Moyes brought Gibson to Goodison Park in 2012 following seven bit-part seasons at Old Trafford between 2005 and 2012.
He would fail to establish himself at the club, however, despite his six-year spell, and is now at Sunderland.
Once a blue, always a blue!
The boyhood Everton fan burst onto the scene as a teenager with a famous strike against Arsenal before then breaking hearts on Merseyside with his big-money move to United in 2004.
Rooney went on to break a string of records at Old Trafford, becoming the club's highest ever goalscorer during a trophy-laden stay in Manchester before sensationally rejoining Everton during the summer.
The current Stoke boss wold leave Goodison after just 18 appearances, however, signing for Blackburn Rovers in 2000.
The winger scored 28 goals in 145 games for United and claimed two Premier League titles, an FA Cup and the 1991 Super Cup.
Everton would later £5m for his services after his falling out with United boss Ferguson, and the Russian would go on to score an impressive 20 goals in 52 games on Merseyside.
If asked to name each player to represent both clubs, most people would forget the name John O'Kane, a member of the aforementioned 'Class of 92' (pictured above, with the defender to be found in the back row, third from the right).
O'Kane was afforded just two senior appearances for the Old Trafford side and left in 1998 to join Howard Kendall's Everton, where he fared little better, managing just 14 league outings before joining Bolton.