The club has been one of many European clubs after the former Ajax Cape Town star's signature.
Serero will become a free agent at the end of this season when he officially cuts ties with Ajax Amsterdam.
And while clubs such as Scottish giants Celtic in addition to Reading have shown interest in his services, it seems as if his search for a new home will continue for a while.
This is after Reading confirmed that they won't be able to get the 26-year-old attacking midfielder.
"He's a quality player, and I would like to get him here, but he won't get a work permit. Your country should be in the top 50 before you can qualify for a work permit in England, which is a new rule, and South Africa is in the sixties, so they don't qualify.
"There's nothing that can be done about it," Reading technical director Brian Tevreden told Vice Sports.
Serero left for Amsterdam in 2011 from feeder club Ajax and has played in dribs, and dabs ever since arriving.