Jose Mourinho has reverted to his tried and tested for a visit from the Seagulls to Old Trafford, with his side seeking to cut the gap to arch-rivals Manchester City at the top of the table.
David de Gea, Antonio Valencia, Ashley Young, Juan Mata, Nemanja Matic and Marcus Rashford among those coming back into the United team. Mourinho makes a total of seven changes, going with the same starting XI as the one which beat Newcastle United 4-1 in their last league fixture.
That means Zlatan Ibrahimovic continues to wait for a start following his return from injury, while Marcos Rojo rests up after making his comeback in Basel.
Brighton boss Chris Hughton makes one change from the side which drew 2-2 with Stoke City on Monday, replacing Jose Izquierdo with Solly March.
Man Utd team: De Gea; Valencia, Smalling, Lindelof, Young; Matic, Pogba; Rashford, Mata, Martial; Lukaku. Subs: Romero, Rojo, Fellaini, Herrera, McTominay, Mkhitaryan, Ibrahimovic.
Brighton team: Ryan; Bruno, Duffy, Dunk, Bong; Knockaert, Stephens, Propper, March; Gross; Murray. Subs: Kayal, Hemed, Goldson, Izquierdo, Schelotto, Krul, Brown.