They are perhaps fortunate that their poorest performance all season is followed by one of the kinder fixtures in the league calendar, with Huddersfield struggling to bring a halt to their recent slide down the table.
But the attitudes on display in United shirts will still have to be spot-on, with the spotlight firmly on the players following their no-show at Wembley. Their title hopes might have been extinguished long ago but they have much to do to secure a Champions League berth.
MAN UTD INJURIES
Eric Bailly remains unavailable after ankle surgery, while Zlatan Ibrahimovic is still attempting to recover from knee trouble following his ACL damage. Marouane Fellaini is also likely to join the injury list after limping out of Wednesday's loss just seven minutes after replacing Paul Pogba as a substitute.
Daley Blind could return after rehabing at Carrington in midweek while the rest of the squad were in London for the Spurs clash.
MAN UTD SUSPENSIONS
United have no suspension issues as they return to the Theatre of Dreams, and the same is true of David Wagner's side.
MAN UTD POTENTIAL STARTING LINE-UP
Wednesday's unacceptable performance is likely to prompt Jose Mourinho into a handful of changes for Huddersfield's visit, with Ashley Young, Phil Jones and Jesse Lingard among those who could make way.
Luke Shaw's recent form has won him a more elevated position in the United squad, and he could return to the starting XI in place of Young, while Marcos Rojo and Victor Lindelof will be on standby for potential call-ups after the trouble United suffered at the heart of their defence at Wembley.
Higher up there could be chances given to Marcus Rashford and Juan Mata as Mourinho looks for the right blend in the forward line following the arrival of Alexis Sanchez from Arsenal.
HUDDERSFIELD TEAM NEWS
After a decent start to their first Premier League campaign, Huddersfield's form has nosedived in the past couple of months. Seven games without a victory, topped off by four straight defeats to Leicester, West Ham, Stoke and Liverpool in which they have conceded 12 goals, sees them heading to Old Trafford in desperate need of the sort of inspiration they were able to muster in beating United 2-1 in October.
Since that famous day in west Yorkshire, David Wagner's side have struggled to reprooduce the sort of stirring form which had seen them take a place in the Premier League mid-table for granted in the early weeks of the campaign. The main problem for the Terriers has been the lack of goals, and Wagner must chose between Steve Mounie and Laurent Depoitre as his best source in front of goal as he looks for greater output from his misfiring front men. So far this season Huddersfield have netted just 19 times in 25 league fixtures.
TV COVERAGE & KICK-OFF TIME
The match at Old Trafford kicks off at 15:00 GMT on Saturday, with live coverage unavailable in the UK due to blackout resctrictions.
BEST OPTA MATCH FACTS
These sides haven’t met at Old Trafford since March 1972, with the Red Devils winning 2-0 in a top-flight fixture with goals from Ian Storey-Moore and George Best.
Huddersfield are winless in their last 14 away games against Man Utd in all competitions (D5 L9) since a 6-0 victory in September 1930.
The last 19 clubs playing their first Premier League match at Old Trafford have all lost – the last team to avoid defeat were Derby County in April 1997, winning 3-2.
Manchester United haven’t lost twice in a league season against a newly promoted side since the 1986/87 campaign, losing both matches against Wimbledon.
Manchester United have lost just two of their last 39 Premier League home games (W24 D13 L2), with both of those defeats coming against Manchester City.
Since the start of last season, Alexis Sanchez has been involved in eight goals in his nine Premier League games against newly promoted sides (7 goals, 1 assist), including a goal against Huddersfield in Arsenal’s 5-0 win against them in November.
Romelu Lukaku has netted 81 goals in 147 games against non ‘big-six’ sides, compared to just 15 goals in 63 Premier League appearances against them (Arsenal, Chelsea, Liverpool, Manchester City, Manchester United and Tottenham Hotspur).