The Reds' 4-0 win over West Ham took them top of the table, but they'll need to be switched on at Selhurst Park - a place which holds mixed memories for supporters.
Liverpool's recent record there is actually pretty good, but Palace themselves started with a decent away win at Fulham and will be relishing the chance to get stuck into Jurgen Klopp's well-backed outfit.
And with the television cameras there for an evening kick-off, there should be a brilliant atmosphere in South East London.
Here, Goal takes a look at everything you need to know ahead of Monday's meeting...
Liverpool will still be without Dejan Lovren, who is a couple of weeks away from returning after an abdominal problem, while Alex Oxlade-Chamberlain is a long-term absentee as he recovers from a knee injury.
But Joel Matip came through a behind-closed-doors friendly at Melwood on Wednesday and could be fit enough to be considered.
Liverpool do not have any suspended players for this game.
Likely Liverpool starting line-up
The quality of Liverpool's performance last week is such that it is hard to make a case for any changes to the starting line-up.
Captain Jordan Henderson could be a consideration, replacing either James Milner or Gini Wijnaldum, but it seems likelier that he, as well as new signing Fabinho and England colleague Adam Lallana, will have to make do with a spot on the bench.
Crystal Palace team news
The Eagles are without defender (and Liverpudlian) Scott Dann, who has a knee injury.
New signing Max Meyer is doubtful as he builds up match fitness, but could feature in the squad. Connor Wickham is another doubt due to a muscle problem.
TV channel & kick-off time
The fixture will be broadcast live in the UK (United Kingdom) on Sky Sports Main Event and Sky Sports Football, kick off 8pm BST.
In the United States , the game can be watched live on television on NBC Sports, kick off 3pm ET.
Best Opta match facts
- Crystal Palace have lost each of their last three home league games against Liverpool – it’s their longest losing home run against the Reds in league competition.
- After a run of three defeats in a row against the Eagles, Liverpool have won four of their last five Premier League meetings with Crystal Palace.
- In all competitions, both teams have scored in 11 of the last 12 meetings between Crystal Palace and Liverpool, with the exception being Liverpool’s 1-0 win at Anfield last term.
- The last Premier League meeting on a Monday between these sides was back in May 2014 – Liverpool were leading 3-0 after 78 minutes before Crystal Palace came back to draw 3-3.
- This will be Liverpool’s 73rd Premier League game played on a Monday, more than any other side in the competition (W33 D20 L19). o Crystal Palace, who have won their last three Premier League games at Selhurst Park, are looking to secure four home top-flight wins in a row for the first time since December 1990 - the fourth game in this run also came against Liverpool.
- Since Jurgen Klopp took charge in October 2015, Liverpool’s Premier League games have seen more goals than any other side (341 – 221 goals, 120 conceded). No side has scored 4+ goals in more different Premier League games than Liverpool in that time (22, level with Man City).
- Crystal Palace’s Wilfried Zaha needs one more goal to become the Eagles’ all-time highest Premier League goalscorer (currently 23, level with Chris Armstrong).
- Liverpool’s Sadio Mané has scored five goals in his seven Premier League appearances against Crystal Palace, more than he has against any other side.
- Crystal Palace striker Christian Benteke has scored six goals in nine top-flight games against former club Liverpool, more than he has against any other current Premier League