A brace from Stephen Sarfo and a strike each by Alfred Okai Quaye and Michael Yeboah were enough to end the visitors' ambitions of defending the title.
In Kumasi, Asante Kotoko continued their impressive run under new coach Steve Polack, by picking their third win in all competitions after pipping second-tier side Wassaman United 1-0 at the Baba Yara Sports Stadium. Captain Amos Frimpong slotted home the only goal of the day from the spot, after Yakubu Mohammed was brought down by Mohammed Lateef in the box.
Elsewhere in Accra, Hearts of Oak needed an own goal from Abdul Rahman Abdullah to defeat Young Wise 1-0, while Amidaus Professionals surprisingly eliminated Ghana Premier League leaders Wafa by a lone goal, thanks to an effort from Daniel Kofi Antwi.
Wa All Stars travelled to Samraboi to post a 2-1 defeat to FC Samartex 1996, with goals coming through David Abagna Sandan and Mathew Kelvin Andoh, while second-tier side Danbort eliminated Liberty Professionals 9-8 on penalties after the game ended 1-1 in regulation time.
Full results at glance:
Asante Kotoko 1-0 Wassaman United
Young Wise FC 0-1 Hearts of Oak
Amidaus Professionals 1-0 Wafa
Danbort FC 1-1 (9-8 pen) Liberty Professionals
Medeama SC 1-0 Elmina Sharks FC
Berekum Chelsea 4-0 Bechem United
Nea Salamina FC 2-0 Steadfast FC
FC Samartex 1996 1-2 Wa All Stars