The Liverpool attacker is the biggest name missing as the Pharaohs' coach Hector Cuper announced a 25-man squad for the final matchday fixture on Wednesday.
The former AS Roma man had headlined a list of 16 foreign-based players announced last month for the Ghana showdown in Cape Coast.
Interestingly, Saudi Arabia-based Mahmoud Abdel-Razik Shikabala, who was not listed in the initial roster, has been added.
Four points clear at the top, Egypt have already secured the sole Group E ticket for Russia 2018, rendering the upcoming fixture a dead rubber.
The Full Squad:
Defenders: Ahmed Elmohamady (Aston Villa, England), Mohamed Abdel-Shafy (Al Ahli, Saudi Arabia), Ahmed Hegazi (West Brom, England), Omar Gaber (Basel, Switzerland), Karim Hafez (RC Lens, France), Rami Rabia (Al Ahly), Ahmed Fathi (Al Ahly) Saad Samir (Al Ahly), Ali Gabr (Zamalek)
Midfielders: Sam Morsy (Wigan Athletic, England), Mohamed Elneny (Arsenal, England), Amr Warda (Atromitos, Greece), Ramadan Sobhi (Stoke City, England), Mahmoud Abdel-Razik Shikabala (Al Raed, Saudi Arabia), Mahmoud Hassan Trezeguet (Kasımpasa, Turkey), Tarek Hamed (Zamalek), Momen Zakaria (Al Ahly) Abdallah El-Said (Al Ahly)