Sundowns, who are the defending champions, are heading into this encounter placed second on the league standings - two points behind the leaders, Wits.
The Brazilians have two games in hand and a victory over the Clever Boys at the Bidvest Stadium will see them climb to the top of the standings.
Many have tipped this mouth-watering clash as a possible title decider, but it is still too early to come to such conclusions as so much can still happen.
Although it is not a title decider, the winner in this match will gain momentum and the belief in the race which still involves former PSL champions Orlando Pirates and SuperSport.
However, Sundowns would take control of the race if they win their two games in hand which would see them open up a four-point lead with 10 matches left.
The Brazilians, who are once again involved the Caf Champions League, have already proved that they are able of juggle between two tournaments and end up winning the PSL title last season.
Pitso Mosimane is well experienced when it comes to dealing with games in hand having translated them into victories last season and he will be ready to do that in this term.
If there is one man, who could outsmart the accomplished coach, it's four-time PSL title-winning coach Gavin Hunt, the Wits mentor.
The Braamfontein-based outfit may be seen as the favourites to win the league title this season due to a lack of continental action as Caf tournaments are known to be very taxing.
Hunt has done it before as he led Wits to their first ever PSL title during the 2016/17 campaign after taking advantage of the fact that they were solely focusing on local competitions.
However, past experiences have made Mosimane and his technical team wiser, and they know exactly what needs to be done in order to retain the coveted trophy.
The 2016 Caf Coach of the Year knows that consistency and good squad rotation will be key to the team's hopes of winning a record-extending ninth PSL title in May 2019.
Furthermore, important players such as attackers Gaston Sirino and Themba Zwane are hitting form at the right time.
The two players were expected to step up and fill voids left by Percy Tau and Khama Billiat, who departed the Brazilians after playing an important role in helping the team win last season's league title.
Zwane has netted five goals in all competitions since the turn of the year, while Sirino has grabbed three assists in Sundowns' last four games.
There is no doubt that the Tshwane giants will stand a good chance of retaining their title if they maintain their good form.