Javier "Chicharito" Hernandez and Hirving Lozano are two of the Europe-based stars to headline Mexico's roster for a pair of upcoming friendlies.
The two games take place in a FIFA window, meaning coach Juan Carlos Osorio will be able to choose from both domestic and foreign-based options.
Monterrey midfielder Jonathan Gonzalez, who made a one-time switch from the U.S. to Mexico in January, has also been named to the roster.
The injury comes at an inopportune time for Dos Santos. The friendlies are the final two games where Osorio can choose from his full compliment of players before he names his preliminary World Cup roster.
After the friendlies against Iceland and Croatia, El Tri don't have another match scheduled until a May 28 friendly against Wales at the Rose Bowl in Pasadena, California.
Full Mexico roster
Goalkeepers: Jose de Jesús Corona (Cruz Azul), Guillermo Ochoa (Standard Liège/BEL), Alfredo Talavera (Toluca)
Defenders: Edson Álvarez (America), Néstor Araujo (Santos Laguna), Hugo Ayala (Tigres), Jesus Gallardo (UNAM), Miguel Layún (Sevilla FC/ESP), Héctor Moreno (Real Sociedad/ESP), Diego Reyes (FC Porto/POR), Carlos Salcedo (Eintracht Frankfurt /GER)
Midfielders: Jonathan dos Santos (LA Galaxy), Marco Fabian (Eintracht Frankfurt/GER), Jonathan González (Monterrey), Omar Govea (Royal Excel/BEL), Andrés Guardado (Real Betis/ESP), Jorge Hernández (Pachuca), Héctor Herrera (FC Porto/POR), Jesús Molina (Monterrey), Rodolfo Pizarro (Guadalajara)
Forwards: Javier Aquino (Tigres), Jesús Manuel Corona (FC Porto/POR), Jürgen Damm (Tigres), Javier Hernández (West Ham/ENG), Raúl Jiménez (Benfica/POR), Hirving Lozano (PSV Eindhoven/NED), Oribe Peralta (América), Carlos Vela (LAFC/USA)