The Portuguese's last comeback in west London did not go well, with United losing 4-0 to the Blues in the Premier League back in October.
Their form has improved since then, but Mourinho's preparation for this game has been hampered by an injury crisis up front. Compounding the problem of Zlatan Ibrahimovic's suspension is the possible absence of Wayne Rooney, Marcus Rashford and Anthony Martial.
|Game||Chelsea vs Manchester United|
|Date||Monday, March 13, 2017|
|Time||19:45 GMT, 15:45 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on BBC One and by stream via the BBC Sport app, with coverage beginning at 19:30 GMT.
|UK TV channel||Online stream|
|BBC One||BBC Sport app|
In the US, the match will be available to watch live on television on FS1 and by stream via Fox Soccer 2Go, with coverage beginning at 15:30 ET and 12:30 PT.
|US TV channel||Online stream|
|FS1||Fox Soccer 2Go|
SQUADS & TEAM NEWS
|Defenders||Ake, Alonso, Azpilicueta, Cahill, Luiz, Moses, Terry, Zouma|
|Midfielders||Chalobah, Fabregas, Hazard, Kante, Kenedy, Loftus-Cheek, Matic|
|Forwards||Batshuayi, Costa, Hazard, Pedro, Willian|
Antonio Conte has a fully-fit squad and, with a 10-point lead in the league and five days until Chelsea's next game, could name his strongest team after rotating for the earlier rounds of the cup.
The most likely first-team regular to be rested is David Luiz, who has been managing a knee problem since late last year and could be replaced by captain John Terry.
Potential starting XI: Courtois; Azpilicueta, Luiz, Cahill; Moses, Kante, Matic, Alonso; Pedro, Costa, Hazard.
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero|
|Defenders||Bailly, Jones, Rojo, Smalling, Blind, Shaw, Valencia, Darmian|
|Midfielders||Pogba, Lingard, Carrick, Herrera, Fellaini, Mata, Young, Mkhitaryan|
United have been hit by a striker crisis. Zlatan Ibrahimovic is serving a three-match ban for violent conduct and Marcus Rashford, his expected replacement, is ill, though he has reportedly travelled with the squad.
To make matters worse, Anthony Martial and Wayne Rooney have been ruled out entirely, with the latter missing the Europa League trip to Rostov on Thursday. Unless Rashford can make a surprise start, Mourinho will have to use either Henrikh Mkhitaryan - who only came off the bench in Russia and is short of match fitness - as a false nine or Marouane Fellaini as a target man.
Luke Shaw joined Rooney in not travelling to face Rostov but is expected to be back in contention for this match.
Potential starting XI: De Gea; Valencia, Bailly, Rojo, Shaw; Herrera, Carrick, Pogba; Mata, Mkhitaryan, Lingard.
BETTING & GAME ODDS
Chelsea are just shorter than odds-on to win on home turf according to Oddschecker, with most bookmakers pricing them at around 5/6. The draw is available at 5/2 and United can be backed at 9/2.
Diego Costa is the favourite to score first at 4/1, with Eden Hazard at 13/2 and Marcus Rashford still the favourite for the Red Devils at 9/1 despite his questionable status with illness. Many bookmakers, however, actually think it is more likely that there are no goals (8/1) than a United player scoring first.
It would take a huge collapse for the Blues to fail to win the championship at this point and as a result they are able to extend their ambitions to other competitions despite relying on a core group of 12 or 13 players who have earned the majority of the playing time this season.
With a strong XI likely, Mourinho will set his team up to keep it tight and demand they defend better than they did in their 4-0 reverse at Stamford Bridge earlier this season.
That kind of approach has been made even more likely by the complete lack of strikers available to the Portuguese, unless Marcus Rashford can recover from illness in time to feature. Few United fans will relish the sight of Marouane Fellaini in the No. 9 role but Henrikh Mkhitaryan as a false nine could allow the Red Devils to congest midfield and make it more difficult for David Luiz to play out from the back.
Otherwise, expect to see David de Gea back in goal despite Sergio Romero taking cup duties so far, Michael Carrick parked in front of the back four and potentially Fellaini joining him to help the defensive effort if not needed in attack.
It will not have escaped either manager's attention that Chelsea have not kept a clean sheet against top-flight opposition in five matches, though it should be noted that the Blues have not conceded more than once in any of those games and two of the goals were meaningless consolations.
Conte will be keen to correct that as Chelsea gear up for the final portion of the season but Mourinho will be hoping the scene is set for one of his classic defensive masterclasses.