The Liverpool star used his pace to burst through Uganda's defenders and then easily placed the ball past Denis Onyango for the winning goal.
Sundowns keeper Onyango is rated as the best stopper in African football so it was an interesting battle against one of Africa's most famous attackers, Mane.
That battle was put to the test for a second time when Onyango saved Mane's penalty late on. One can read how fans across the continent reacted to Onyango's penalty save, hailing him as Africa's best. Though, many critics believe Onyango should have been sent off before that save.
There are also plenty of comments on Mane's heroics, despite not scoring two penalties in the tournament so far.
Thanks to SuperSport TV's official Twitter we can also watch these two incidents right here.
Aliou Cissé edging closer. #Afcon2019— Mazola J. Molefe (@superjourno) July 5, 2019
So Denis Onyango who is on a yellow card commits a foul and a penalty is awarded (which I feel a second yellow card was warranted).He gets away without and goes on to save a penalty giving Sadio Manè a second penalty saved in this tournament.— Amanda toki Dlamini (@Amanda_Dlamini9) July 5, 2019
How does he get away with it..?😳🤷🏻♀️😱
Senegal are through to the Quaterfinals of the #AFCON2019 after beating Uganda 1:0 in a round of 16 clash.— Alfred Jones ⚽️🇰🇪 (@alfredjones254) July 5, 2019
FT: Uganda 🇺🇬 0-1 🇸🇳 Senegal
Sadio Mané⚽#TotalAFCON2019 #UGASEN #AFCON2019 #UgandaCranes #LionsDeLaTeranga pic.twitter.com/0NEY1lQ6E1
#UGASEN #AFCON2019— Apuuli-the-Mafia (@AllanApuuli) July 5, 2019
Liverpool: Sadio Mane is our hero.
Barcelona: we fear Mane.
Premier League: Mane is a tiger.
Champions League: damn Mane!
Senegal : Mane is the GOAT.
Onyango : who the f"$%@ is Mane? pic.twitter.com/bhrYlmPV5R
That Onyango save is our Afcon Trophy we don't need anything else— Soldier↪ (@PatohShanqueels) July 5, 2019
Ugandan women now when they see onyango. pic.twitter.com/CTCBfK0UV0— 🇺🇬 (*THE VIOLIST*) (@Fynst_stalker) July 5, 2019
This Man is the greatest Ugandan!— GEÖFF-OBBO 🎩 (@geoffobbo13) July 5, 2019
Please retweet this until I marry Onyango.😆— Monica (@Monica_UG) July 5, 2019
Onyango was showing off.— Edwin B. Wabwire (@ewabwire2008) July 5, 2019
Gave away a penalty and saved it.
Onyango is the best goalkeeper in Africa pic.twitter.com/SLHd0v6oA4— Collins Kasembeli (@kasembeli_afc) July 5, 2019
Someone has said Onyango would have saved Titanic if he was in those times 😂😂😂🙌🏻— That_Gharl (@Yofav01) July 5, 2019
Onyango is a super hero🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬🇺🇬✊🏾✊🏾🇺🇬— Collins Muhumuza ⛱ (@collins__m) July 5, 2019
Rt for onyango & that penalty🤣🤣🤣
I wonder i juve had to take in Buffon again yet onyango is here pic.twitter.com/Fd7prCDiI8— kityo Ronald (@kityo256) July 5, 2019