Aduana are making a return to the competition for the first time since 2011 while Tahadi are returning after a 40-year hiatus. This will be the second time running that a Ghanaian club will lock horns with a club from Libya at the prelims.
Ahly Tripoli eliminated Wa All Stars from the competition last season following a 5-1 aggregate.
The Porcupine Warriors are making a return after they were eliminated by MC Eulma in 2015.
The first leg will be played on the weekend of February 9-11, 2018 at the Baba Yara Sports Stadium in Kumasi and, the second leg is expected to take place on the weekend of February 20-21 2018 in Brazzaville.
The winner will meet the winner between Tunisian side Ben Guerdane and Al Hilal Juba of Sudan.