With the Gunners in FA Cup action, Ronald Koeman's men can at least temporarily climb into sixth by claiming a point at the London Stadium.
With the Hammers stretched by injuries and suspensions and Romelu Lukaku in top form, however, they may be hoping for more as they look to end a five-game winless run away from home.
|Game||West Ham vs Everton|
|Date||Saturday, April 22, 2017|
|Time||15:00 GMT, 10:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will not be available to watch live due to the blackout imposed between 2.45pm and 5.15pm on Saturdays.
|UK TV channel||Online stream|
In the US, the match will be available to watch live on television on NBC Premier League Extra and by stream via NBC Sports Live.
|US TV channel||Online stream|
|NBC Premier League Extra||NBC Sports Live|
SQUADS & TEAM NEWS
|Position||West Ham players|
|Goalkeepers||Randolph, Adrian, Spiegel|
|Defenders||Reid, Cresswell, Collins, Byram, Masuaku, Arbeloa, Fonte|
|Midfielders||Kouyate, Nordtveit, Feghouli, Fernandes, Lanzini, Snodgrass|
|Forwards||Sakho, Ayew, Calleri, Fletcher|
West Ham are without Michail Antonio, Andy Carroll, Pedro Obiang, Angelo Ogbonna and Gokhan Tore due to injury, but Winston Reid is back in contention after a groin problem. Sam Byram and Mark Noble, meanwhile, are both suspended.
Cheikhou Kouyate could fill in for Byram at right-back, leaving Havard Nordtveit to step into his place in central midfield.
Potential starting XI: Randolph; Kouyate, Fonte, Collins, Masuaku; Snodgrass, Nordtveit, Fernandes, Lanzini; Ayew, Sakho.
|Defenders||Baines, Jagielka, Williams, Holgate, Kenny|
|Midfielders||Mirallas, Barry, Barkley, Gueye, Davies, Schneiderlin|
|Forwards||Kone, Lukaku, Calvert-Lewin, Lookman|
Enner Valencia is not eligible to play for Everton against his parent club, while Aaron Lennon and James McCarthy are yet to return and Ramiro Funes Mori, Yannick Bolasie and Seamus Coleman are long-term absentees.
Muhamed Besic is back in training after a long lay-off with a knee injury but still at least a week away from being in first-team contention. With his squad stretched thin, Koeman could name an unchanged side.
Potential starting XI: Robles; Holgate, Jagielka, Williams, Baines; Gueye, Schneiderlin, Davies; Barkley, Lukaku, Mirallas.
BETTING & GAME ODDS
Everton are 5/4 favourites to win away from home, according to Oddschecker, with West Ham priced at 12/5 and the draw available at 11/4.
Romelu Lukaku is tipped to score first at 7/2, with Diafra Sakho the top choice for the Hammers at 15/2 and Kevin Mirallas available to back at 8/1.
Everton can rise above Arsenal with a point at West Ham, and though the Gunners will have three games in hand by the end of the weekend their inconsistent form has made stealing sixth place seem a realistic target for the Toffees.
Ronald Koeman's men have been near unbeatable at home of late, and could have a part to play in the Premier League title race when Chelsea visit Goodison Park at the end of the month. Away they have found it tougher, however, and are winless in five, though trips to Manchester United, Tottenham and Liverpool have featured in that run.
They will hope to end that streak against a Hammers team as stretched by various absences as they are, and blunted by the latest injury suffered by Andy Carroll. With Michail Antonio also out and little for Slaven Bilic's men to play for, it is not a bad time to visit London Stadium.
Everton will be significantly more potent as long as Romelu Lukaku is chasing the Golden Boot. The striker's sensational recent form has seen him build a four-goal lead over Harry Kane, and with 24 to his name with five games left he has an outside shot at hitting 30.