Seemingly in disrepair when David Moyes took over following the sacking of Slaven Bilic, the Hammers have put together an impressive run of form, despite their mediocre 0-0 FA Cup draw with Shrewsbury Town last time out.
Prior to that encounter, the Hammers drew 1-1 with bitter rivals Tottenham at Wembley, and will hope for a repeat performance this time out against David Wagner's sprightly Terriers.
WEST HAM INJURIES
Winston Reid is a major doubt for the encounter after sustaining a groin injury in the 0-0 draw with Shrewsbury at the weekend, but Marko Arnautovic is set to play after overcoming a tight hamstring.
Michail Antonio, too, could play a cameo role following a groin problem of his own. Aaron Cresswell, however, remains a doubt owing to a back problem.
Diafra Sakho, James Collins, Sam Byram and Jose Fonte are all set to miss out.
WEST HAM SUSPENSIONS
West Ham have no suspended players.
WEST HAM STARTING LINE-UP
Moyes picked a strong team for his side's encounter with Shrewsbury, and was given little in return as the Hammers huffed and puffed and were perhaps outplayed by their lower-league opposition.
Adrian is likely to return in goal, despite Joe Hart captaining the side and keeping a clean sheet against his former employers, while Mark Noble should play in midfield after being rested at the weekend.
Manuel Lanzini, too, will return to the fold, though Winston Reid's injury may force Moyes into a return to a 4-4-2 formation, with potential replacement James Collins also crocked.
Below is a possible XI for the Hammers.
HUDDERSFIELD TEAM NEWS
Collin Quaner is set to miss out with a hamstring injury, while defender Martin Cranie is a doubt with an ankle problem.
Chris Lowe has a foot injury and is doubtful, while Elias Kachunga and Jon Gorenc Stankovic are long-term absentees.
TV CHANNEL & KICK OFF TIME
The match takes place at 15:00 GMT (10:00 ET) on Saturday and will not be shown live in the UK. Highlights can be caught on BBC's Match of the Day at 22:30 GMT.
In the United States (US), Premier League matches can be watched live and on-demand with fuboTV (7-day free trial).
BEST OPTA MATCH FACTS
Huddersfield have won 10 of their last 12 home league games against West Ham (W10 D1 L1), though this is the first such meeting since a 1-0 win in November 1971.
West Ham won the reverse fixture 2-0 back in September – they’ve never won both league games against Huddersfield in any of the previous 15 seasons they’ve met.
Excluding own goals, just six different players have scored a Premier League goal for Huddersfield this season; no side has had fewer (level with Brighton).
Marko Arnautovic has scored in his last two Premier League away games; only five players have ever scored in 3+ consecutive games on the road for West Ham in the competition, most recently Diafra Sakho in October 2014.