But to achieve success against Manchester City, they will need midfield maestros, Moussa Sissoko and Christian Eriksen, to maintain the fine form they have both enjoyed in Europe this season.
Eriksen, who scored against City in the UCL for Ajax in 2012, ranks eighth among all players for sequences ending in a shot this season, while Sissoko, now integral to Spurs' engine room, has created three big chances in Europe's premier club competition - only Eriksen (6) has created more for Spurs.
Both players are flourishing thanks to the foundations Mauricio Pochettino has laid during his time in north London - will his side triumph against the Premier League champions?
Watch the video above for the statistics and full breakdown.
Throughout the 2018-19 season, the 'Innovation Champions' series will highlight the Intelligent Movement of Europe's top teams. Follow the series on Facebook at Nissan Football Lab.