Spurs faced yet more semi-final heartbreak last weekend, as Manchester United fought back from 1-0 down to win 2-1 at Wembley.
The result came on the back of defeat to Manchester City and a dour draw with Brighton and Hove Albion and, with Chelsea still in the race to qualify for the Champions League, Spurs have to start picking up points soon.
Watford, meanwhile, are all but safe in 12th, nine points clear of the relegation zone, but they can still finish in the top 10 if they can put together a string of positive results between now and the end of the season.
Danny Rose is out with a calf strain and will almost certainly be replaced by Ben Davies in the Spurs XI.
Elsewhere, Harry Winks remains on the sidelines, but he does not need surgery on an ankle injury that has been bothering him throughout the 2017-18 campaign.
With four Premier League matches remaining, Mauricio Pochettino said on Friday that it "will not be easy for him [Winks] to play again this season".
Tottenham have no players currently serving a ban.
Tottenham potential starting line-up
There remains a question mark over the fitness of Harry Kane for Pochettino, but he is likely to lead the line against Watford.
The England international struggled against United, and it appears that he is still being bothered by the ankle injury he sustained earlier this year.
Son Heung-Min played a major part as his deputy during Kane's injury and would be able to play through the middle if the striker were rested.
Hugo Lloris will return in goal after Michel Vorm played in the FA Cup semi-final, while Pochettino will also have a decision to make in central defence; Toby Alderweireld is fit to play and returned to the fold against Brighton last week, but it remains to be seen if he will play or Davinson Sanchez will continue alongside Jan Vertonghen.
Watford team news
The big news out of Javi Gracia's pre-match press conference is that Gerard Deulofeu could play a part after returning to training, while – contrary to reports – Troy Deeney is fit and ready to play.
Stefano Okaka will miss the rest of the season with a thigh issue, while Roberto Pereyra faces a late fitness test.
Tom Cleverley, Nathaniel Chalobah, Younès Kaboul and Tommie Hoban will all miss the clash as they continue their respective rehabilitations.
TV channel & kick-off time
The fixture will be broadcast live in the UK (United Kingdom) on Sky Sports, and kicks off at 20:00 BST.
Best Opta match facts
- Tottenham are unbeaten in their last 12 matches against Watford in all competitions (W9 D3), since a 3-2 defeat at White Hart Lane in the League Cup in October 1994.
- Watford have lost their last seven away league matches against Spurs since a 5-1 win in May 1985 under Graham Taylor.
- Tottenham have lost their last two home games in all competitions, as many as they had in their previous 42 combined. They’ve not lost three in a row at home in the same season since November 2004 (a run of four).
- The Hornets have failed to score in four of their last six Premier League games (W0 D2 L4).
- Christian Eriksen has been directly involved in eight goals in his last seven games in all competitions (5 goals, 3 assists).
- Mauricio Pochettino’s side haven’t gone four games without a win in all competitions since a run of seven in October/November 2016.