Spurs occupy fourth spot at present, but are only five points clear of the Blues and could be left sweating on Champions League qualification come Sunday afternoon.
Mauricio Pochettino’s side will need no reminding of their dismal record at Stamford Bridge down the years, but they do remain without a Premier League win in west London – with Gary Lineker the last man to score a winner for them on the road back in February 1990.
Here, Goal takes a look at everything you need to know ahead of the game.
Tottenham head coach Pochettino has hinted that leading marksman Harry Kane could be involved, but he is still nursing an ankle injury and Son Heung-min is more likely to continue deputising as a central striker.
Erik Lamela should fill in on the flanks, with Kane expected to return against Stoke on April 7 – with Spurs and England hoping to see him slot seamlessly back into the fold.
Toby Alderweireld made his comeback for Belgium in midweek, so could be handed a domestic recall amid uncertainty surrounding his future, but Harry Winks remains sidelined with an ankle complaint.
Tottenham have no players currently serving a ban.
Tottenham potential starting line-up
Pochettino is unlikely to tinker too much with a side that has collected four successive Premier League victories and suffered just one defeat in 20 across all competitions.
Hugo Lloris, Mousa Dembele and Dele Alli are likely to be rotated back in from the side which saw off Swansea in the FA Cup last time out, but continuity is the order of the day at this stage of the season.
Chelsea team news
Thibaut Courtois and Andreas Christensen are expected to figure for Chelsea despite nursing knocks through the international break, but Ross Barkley (hamstring) and David Luiz (ankle) are likely to miss out.
Alvaro Morata scored in his last appearance – an FA Cup win over Leicester – and Olivier Giroud was among the goals for France while away with his country, giving Antonio Conte a big decision to make up front following his recent experiment with Eden Hazard in a false nine role.
TV channel & kick-off time
The fixture will be broadcast live in the UK (United Kingdom) on Sky Sports Premier League from 15:30 GMT.
In the United States, the game can be watched live on television on NBCSN and kicks off at 11:00 ET.
Best Opta match facts
Spurs’ 25 games at Stamford Bridge without winning in the Premier League is the most that one team has played on one ground without a single victory in the competition.
Tottenham have won more points in Premier League London derbies this season than any other side (13 – W4 D1 L2).
Spurs have surrendered the lead on each of their last two league visits to Stamford Bridge, drawing 2-2 from 2-0 up in May 2016, and losing 2-1 after Christian Eriksen gave them the advantage last term.
Chelsea are looking to secure back-to-back Premier League wins for the first time since December – they’re winless in their last four against fellow ‘big six’ sides (D2 L2), although all of those have been away from home.
After a run of nine games in all competitions without a goal, Son Heung-min has scored seven in his last five for Tottenham.
Under Mauricio Pochettino, Tottenham have won 59% of their Premier League games in which Harry Kane has featured (won 77/131) compared to just 39% when he’s played no part (5/13).