The Saints have been underperforming this season and find themselves among the bottom pack thanks to a run of 10 Premier League games without a win.
Spurs, on the other hand, are in excellent form, and travel to the south coast on the back of a magnificent 4-0 win over Everton to keep them within touching distance of the top four.
|Game||Southampton vs Tottenham Hotspur|
|Date||Sunday, January 21|
|Time||16:00 GMT / 11:00 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV CHANNEL & LIVE STREAM
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
In the United Kingdom (UK), the game.can be watched live on TV on Sky Sports and it can be streamed live online using the Sky Go app.
|UK TV channel||Online stream|
|Sky Sports Premier League, Sky Sports Main Event||Sky Go app|
SQUADS & TEAM NEWS
|Defenders||Bertrand, Stephens, Yoshida, Hoedt, Soares, Pied, Gardos, Bednarek, Targett|
|Midfielders||Romeu, Lemina, Hojbjerg, Ward-Prowse, Davis, Boufal, Tadic|
|Forwards||Redmond, Long, Sims, Gabbiadini|
Mauricio Pellegrino is still without Charlie Austin as the forward is a long-term injury absentee after tearing his hamstring in December.
Maya Yoshida is a doubt for Sunday's game with a hamstring problem, but could still be included in the matchday squad.
Potential Southampton starting XI: McCarthy, Soares, Stephens, Hoedt, Bertrand, Romeu, Hojbjerg, Ward-Prowse, Tadic, Boufal, Long.
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Davies, Aurier, Vertonghen, Sanchez, Dier, Foyth, Trippier, Walker-Peters|
|Midfielders||Wanyama, Sissoko, Dembele, Alli, Eriksen, Lamela|
|Forwards||Kane, Son, Llorente|
Mauricio Pochettino faces a late decision over the fitness of goalkeeper Hugo Lloris, who has been forced to sit out training midweek due to illness. Michael Vorm could start should Lloris miss out.
Defenders Danny Rose and Toby Alderweireld are both sidelined, while Harry Winks has an ankle injury.
Potential Tottenham starting XI: Lloris, Aurier, Sanchez, Vertonghen, Trippier, Dier, Dembele, Eriksen, Alli, Son, Kane.
BETTING & MATCH ODDS
Spurs are favourites to win at 4/6 according to dabblebet, but Southampton are not far behind at 9/2. A draw is available at 14/5.
While Southampton will be looking to record an overdue win in the league, having failed to pick up three points in any of their games in December or January. A 1-0 away victory over Fulham was a reminder that the Saints are capable of better than they have shown, but they are still not doing enough up front.
Shane Long finally broke his goal drought, but their top scorer this season is Charlie Austin with six goals, and he is currently injured.
Goals have been much easier to come by for Spurs, with Harry Kane finishing the year in style and then picking up where he left off in January. The England international has 20 Premier League goals so far this season, with Heung-Min Son already on eight for the 2016-17 campaign.
Spurs' defence has also been excellent this season, even with injuries ruling some key players out, and average less than a goal against each game. Southampton will find it difficult to record a win against Pochettino's side, and will likely see their run extend to 11 league games without a win.