The Black Stars finished second in Group D while the Leopards topped Group C.
Ghana are in search of a sixth consecutive qualification to the last four of the tournament since 2008.
Camille, 41, is not new to Ghanaian teams. He took charge of the Black Stars' 2-1 defeat to Senegal in the opening game of the 2015 Afcon and recently, was the centre man in Medeama's 3-1 defeat to South African side Mamelodi Sundowns in the 2016 Caf Confederations Cup knockout stage in Pretoria.
Camille will be assisted on the lines by Nigerian referee Abel Baba and Mohammed Abdallah Ibrahim from Sudan.
Interestingly, the last time Camille officiated a game involving DR Congo, was in the quarterfinals of the 2015 edition, where they defeated their neighbours Congo 4-2 to advance to the semi-finals only to lose to eventual winners Cote d'Ivoire.
Ghana are without Baba Rahman, who has been ruled out of the tournament, and are sweating over the fitness of captain Asamoah Gyan, although reports suggest the all-time topscorer of the team could play a part in the game after arriving in Oyem following medical tests on Thursday.
The Black Stars are in search of their first silverware since 1982, having lost three Afcon finals between 1992 and 2015.